Clinical Analysis Of Endocrine And Metabolic Disorders In Patients With Polycystic Ovarian Syndrome

Background: Polycystic ovarian syndrome(PCOS)is one of the foremost common gynecological endocrine diseases.It is a hormonal disorder common among women of reproductive age.It’s currently the leading explanation for anovulatory infertility.The incidence rate is 5% to 10% in women of childbearing age.About 70% of patients with infertility.Patients with PCOS may have infrequent or prolonged menstrual periods or excess male hormone(androgen)levels.The ovaries may develop numerous small collections of fluid(follicles)and fail to regularly release eggs.The disorder of endocrine levels in PCOS patients results in high estrogen,high androgen,and low progesterone levels within the body,eventually resulting in reduced endometrial receptivity.Abdominal obesity and insulin resistance stimulates ovarian and adrenal androgen production,whereas SHBG levels are decreased.Abdominal obesity and increased activation of the inflammatory system is seen in both normal weight and obese PCOS patients leading to an increased risk of dyslipidemia,diabetes.Androgen excess plays a major role in the development of PCOS associated metabolic disorders,with notable effects on major peripheral metabolic tissues,particularly adipose tissue,and the liver,pancreas and muscles,and especially the brain,contribute to the constellation of metabolic complications,from PCOS,obesity to insulin resistance.However,the current understanding of the pathogenic role of hyperandrogenism in the metabolic dysfunction of PCOS and the underlying mechanisms is still incomplete.In addition,the development of more effective or even personalized therapeutic strategies for the metabolic of PCOS patients continues to be an unmet need and it is certainly beneficial to better understand the molecular basis of this heterogeneity syndrome.An out-sized number of studies suggest that the explanation for this outcome could also be the complex endocrine and metabolic changes in PCOS patients.The event depends on progesterone,and estrogen,restricts its development.Proper levels of estrogen and progesterone can promote embryonic and intimal developmental synchrony and increase planting rates.Patients diagnosed with PCOS therefore should be screened for elements in the metabolic syndrome including weight,waist,blood pressure,Hb A1 c,and lipid status.Furthermore,more data are needed to determine the endocrine and metabolic risk in different subgroups ofpatients with PCOS.Purpose: Clinical analysis of endocrine and metabolic disorders in patients with polycystic ovarian syndrome.Material and Method: A retrospective cohort study was conducted on patients attending the Third Affiliated Hospital of Xinxiang Medical College.This study conducted a retrospective analysis of 156 patients with polycystic ovary syndrome diagnosed according to Rotterdam’s criteria who were admitted to the Department of Obstetrics and Gynecology in our hospital from January 2018 to November 2020.The age of the patients was 16-35(mean,24.78 ± 3.69)years old.Married patients accounted for 60.89%(95/156)and 35.69%(34/95)had a history of pregnancy.Unmarried patients accounted for 39.10%(61/156).Adolescent and adult patients accounted for 8.97%(14/156)and 91.03%(112/156)respectively.Based on Rotterdam criteria,the 156 patients were divided into 4 phenotype groups as the following: type I(N=44): type II(N=34): and 2);type III(N=29);and type IV(N=49).My research design is to target this group of patients and evaluate the clinical results to observe the improvement of the quality of life,which will also help further research and development.Result: Among 156 patients with polycystic ovary syndrome,100(64.10%)had dyslipidemia.The endocrine and metabolic disorders ofpatients with polycystic ovary syndrome were analyzed.There is no significant difference between BMI and WHR between the I-IV groups in Table I-III;the BMI and WHR of the NOB group and the NHI group are significantly lower than the OB and HI groups,respectively.The lipid indices TG,TC,LDL-C,and HDL-C showed no significant differences among groups I-IV;however,TG,TC,and LDL-C in OB and HI groups were significantly higher than those in NOB and NHI groups respectively,but HDL-C levels in OB and HI groups were significantly lower than those in NOB and NHI groups respectively.Conclusion: Polycystic ovary syndrome is a multifactorial hormone-related disease.I found that about 64.10% patients had dyslipidema while there was no significant change between body mass index and waist hip ratio among I-IV groups.Endocrine and metabolism disorders in patients with polycystic ovary syndrome showed dyslipidemia,obesity and insulin resistance,leading to increased androgen secretion and decreased SHBG levels.