| Objective: To observe the clinical effect of Mahuang Shengma Decoction on children enuresis with sinking of yang qi and flaming upward of deficiency fire by recording and analyzing the change of syndrome score before and after medication,and to lay a foundation for further exploration and research on the clinical application of Mahuang Shengma decoction.Methods: This clinical trial will meet the standards of 66 children with enuresis of sinking of yang qi and flaming upward of deficiency fire randomly divided into experimental group and control group,experimental group of 35 cases,3 cases shedding,the actual clinical observation cases of 32 cases;There were 31 cases in the control group,and 1 case fell off.The actual number of clinical observation cases was30.The experimental group was given Mahuang Shengma Decoction granules,and the control group was given desmopressin acetate orally.The course of treatment was set to 4 weeks.Clinical observation nodes were set before medication,2 weeks after medication and 4 weeks after medication to compare the syndrome scores and total clinical efficacy of the two groups.In addition,the children whose clinical efficacy was evaluated as effective were followed up 8 weeks after drug discontinuation,and the recurrence situation was recorded and compared.Results:1.General information: Age,gender,course of disease and syndrome scores before treatment were compared between the two groups.Chi-square test showed that P >0.05,indicating that the difference was not statistically significant and was comparable.2.Efficacy: After the 4-week treatment course,the effective rate of the experimental group was 93.75% and that of the control group was 83.33%.Chi-square test showed that P <0.05,indicating that the difference was statistically significant.3.Relapse situation: 8 weeks after drug discontinuation,the children whose efficacy was evaluated as effective,effective or cured in the two groups were followed up.The recurrence rate was 8.7% in the experimental group and 38.1% in the control group,and the difference was statistically significant(P < 0.05).4.The syndrome integral aspects:(1)Comparison of main symptom scores: After 2 weeks of treatment,there was no significant difference in main symptom scores between the two groups(P > 0.05);After 4 weeks of treatment,the difference was statistically significant(P < 0.05).(2)Comparison of scores of secondary symptoms: The test showed that there were statistically significant differences in scores of secondary symptoms between the two groups after 2 weeks and 4 weeks of medication(P < 0.05);(3)Comparison of total scores: The test showed that there was no statistically significant difference in total scores between the two groups after 2 weeks of treatment(P > 0.05),but there was statistically significant difference after 4 weeks of treatment(P < 0.05).Conclusion: Both of the two treatment schemes for children with enuresis have exact clinical efficacy,both can effectively reduce the number of enuresis,reduce the threshold of recovery,and improve the rate of arousal.After 2 weeks of treatment,clinical observation was conducted,and the syndrome score was compared and analyzed,indicating that the control group was superior to the experimental group in reducing the frequency of bedwetting,indicating that the control group could be effective in the short term.At the end of the course,the two groups showed similar improvement in the frequency of enuresis.However,the experimental group had better effect in improving the sleep of children,and could more effectively treat the pharyngeal symptoms,hyperactivity less quiet,night sleeping restlessness and other syndromes,and the overall effect was better than the control group.In addition,the follow-up results showed that the trial group had a lower recurrence rate.Therefore,Mahuang Shengma decoction in the treatment of children enuresis with sinking of yang qi and flaming upward of deficiency fire effect is accurate,stable,not easy to relapse,worthy of clinical application. |
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