| Objective:The clinical significance of serum alkaline phosphatase(ALP)in patients with hyperthyroidism was investigated by observing the levels of serum alkaline phosphatase(ALP)in patients with hyperthyroidism and observing the changes in serum ALP levels before and after anti-thyroid drug treatment.Methods:Patients who attended the outpatient clinic of the Department of Endocrinology of Linfen People’s Hospital and met the diagnostic criteria of hyperthyroidism and the criteria of nadir in the hyperthyroidism group were selected and included in the hyperthyroidism group.In addition,patients with normal thyroid function who underwent health checkup at Linfen People’s Hospital during the same period and met the criteria for inclusion in the control group were selected and included in the control group.The clinical data of all the enrolled individuals were recorded,and the differences between the clinical data of the two included groups were compared.Correlation analysis was used to analyze the correlation between serum alkaline phosphatase and thyroid function indexes;binary logistic multi-factor regression analysis model was used to analyze the risk factors of elevated serum alkaline phosphatase.Results:(1)The serum alkaline phosphatase level in the hyperthyroidism group was [126.50(94.00167.70)] U/L,which was significantly higher than that in the control group [66.4(56.30,79.20)] U/L.The serum alkaline phosphatase level in the hyperthyroidism group significantly decreased after 1 month and 6 months of anti-thyroid drug treatment,and the difference was statistically significant.(2)Spearman correlation analysis showed that serum alkaline phosphatase levels were positively correlated with free tetraiodothyronine(FT4)and free triiodothyronine(FT3)in the hyperthyroid group(r values of 0.537 and 0.587,respectively,P < 0.01)and negative correlation with thyroid-stimulating hormone(TSH)(r=-0.496,P<0.01).(3)Binary logistic multiple factor regression analysis showed that elevated levels of FT4 and GGT,while decreased levels of TSH were independent risk factors for elevated serum alkaline phosphatase.Conclusions:Patients with hyperthyroidism may have elevated serum alkaline phosphatase levels.thyroid hormone and thyroid hormone act on the liver and bone system through various mechanisms,resulting in elevated serum alkaline phosphatase levels.After 6 months of treatment with antithyroid drugs,patients with hyperthyroidism regained normal thyroid function and their serum alkaline phosphatase levels decreased to levels close to those of the normal control group.In clinical practice,patients with hyperthyroidism should actively receive anti-thyroid drug treatment and monitor liver function.After thyroid function is restored,liver function indicators can return to normal levels.At the same time,improve the examination of bone metabolism indicators,timely detect changes in bone mass,and intervene early to improve the quality of life of patients with hyperthyroidism. |
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