Influence Of Left Ventricular Myocardial Mechanics On Right Ventricular Longitudinal Strain In Hypertrophic Cardiomyopathy

Objective:This study evaluated the myocardial strain of the right ventricle(RV)in hypertrophic cardiomyopathy(HCM)without RV involvement and further explored the effect of left ventricle(LV)systolic and/or diastolic function on the RV.Methods:Thirty patients with HCM and 24 healthy volunteers were included.Cardiac MR cine were acquired,and feature tracking parameters,including LV global peak strain,systolic and early diastolic strain rates in all orientations,global longitudinal peak strain(GLS),and systolic and early diastolic strain rates of the RV free wall,were evaluated.Cardiac function and myocardial strain were compared between the HCM and healthy groups.The correlation of myocardial strain between LV and RV was explored.Results:Global radial peak strain(GRS)(31.1±8.9 vs.38.5±9.1,p<0.05),GLS(-9.1±2.4 vs.-14.1±1.8,p<0.05),global systolic longitudinal strain rate[-0.57(-0.73～-0.45)vs.-0.79(-0.93～-0.67),p<0.05],and radial(-2.03±0.69 vs.-2.57±0.77,p<0.05),circumferential(1.06±0.27 vs.1.32±0.28,p<0.05)and longitudinal(0.53±0.15 vs.0.81±0.21,p<0.05)early diastolic strain rate in the LV and GLS in the RV[-10.8(-13.5～-8.0)vs.-14.0(-17.1～-12.3),p<0.05]were significantly lower in the HCM group than healthy group(all P<0.05).Multiple linear regression analysis revealed that the GRS and GLS of the LV potentially affected the GLS of the RV(adjusted R~2=0.35,P<0.05).For every percent added of LV GRS and GLS,RV GLS increased by 0.443%and 0.409%,respectively.Conclusion:HCM without RV hypertrophy and preserved EF in RV showed strain impairment.LV systolic function has potential influence on RV longitudinal systolic function,which related to the prognosis of HCM in previous study.We suggest that in addition to LV diastolic function,clinicians consider LV systolic function and RV longitudinal systolic function.