| Objective:To investigate levels and significance of total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),high density apolipoprotein A-Ⅰ(Apo A-Ⅰ),high density apolipoprotein A-Ⅱ(Apo A-Ⅱ),serum amyloid protein A(SAA),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)in patients with chronic obstructive pulmonary disease(COPD)in stable and acute exacerbation(AECOPD)with or without coronary artery disease(CAD).Methods:A total of 160 patients with COPD treated in our hospital from January 2020 to June2022 were selected as the experimental group,and divided into 4 groups according to COPD in acute or stable stage and whether CAD was combined: stable COPD group,AECOPD group,stable COPD with CAD group,AECOPD with CAD group.Twenty healthy people in our hospital during the same period were selected as control group.General data and levels of TC,HDL-C,Apo A-Ⅰ,Apo A-Ⅱ,SAA,TNF-α and IL-6 were analyzed in each group.Results:1.There were no statistical differences in the levels of TC and HDL-C between the experimental group and the control group(P>0.05).2.The levels of Apo A-Ⅰ and Apo A-Ⅱ in AECOPD group,AECOPD with CAD group were significantly lower than those in COPD stable stage group,COPD stable stage with CAD group and control group(P<0.01).The levels of SAA,TNF-α and IL-6 were significantly higher than those of stable COPD group,stable COPD combined with CAD group and control group(P<0.01).3.There were no significant differences in the levels of SAA,TNF-α and IL-6 in AECOPD combined with CAD group compared with AECOPD group(P>0.05).4.The levels of TNF-α and IL-6 in COPD stable stage combined with CAD group were not significantly different from those in COPD stable stage and control group(P>0.05),while the level of SAA was significantly increased(P<0.01).Conclusion:The level of SAA in COPD combined with CAD was significantly higher than that in COPD combined with CAD,suggesting that the increase of SAA may play a role in the development of COPD combined with CAD. |
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