| Objective:To investigate the effects of HDP on the digestive system,hypoglycemia and thyroid function in preterm infants born to mothers with hypertensive disorders of pregnancy(HDP)at gestational age <32 weeks,and to provide a theoretical basis for the perinatal management of pregnant women with HDP and preterm infants.Methods:In a retrospective approach,180 preterm infants with gestational age <32 weeks who were born in the obstetrics department of Linyi People’s Hospital and Linyi Central Hospital between January 1,2020 and December 31,2021 and transferred to the neonatal intensive care unit of the corresponding hospitals immediately after birth were selected as the observation scope.Among them,80 cases of preterm infants born to HDP mothers were the study group,and 100 cases of preterm infants born to non-HDP mothers with gestational age<32 weeks were selected as the control group.The above clinical data were studied by statistical analysis.Results:1.Comparison of general data: The analysis of variance showed that the occurrence of a family history of hypertension(χ2=4.202,P=0.040),prenatal fetal intrauterine distress(χ2=8.418,P=0.004),and whether the child was younger than gestational age(χ2=26.591,P<0.001)was higher in the HDP group than in the non-HDP group,and birth weight(t=5.552 The median Apgar score at 1 minute was 7 in the HDP group and 8 in the control group,with a statistically significant difference(P=0.018)and no statistically significant difference in the Apgar score at 5 minutes(P=0.313);the median gestational age in the study group was30.57±1.11 weeks,which was greater than The median gestational age in the study group was 30.57±1.11 weeks,which was greater than that in the control group of 30.12±1.18 weeks,and the difference between the two groups was statistically significant(P=0.010).There were no statistically significant differences in maternal age,prenatal application of hormones,the occurrence of premature rupture of membranes(≥18 hours),mode of delivery,history of adverse pregnancy and delivery,sex of preterm infants,and whether singleton or multiple births(P>0.05).2.Comparison of the digestive system of preterm infants: As shown by the analysis of variance,the occurrence of abdominal distension between groups was higher in the HDP group(χ2=4.411,P=0.036)than in the control group,and the number of days in hospital(Z=3.503,P<0.001)and the corrected gestational age at discharge(t=-6.901,P<0.001)were greater in the study group than in the control group,with statistically significant differences in each data;complete The median duration of transoral feeding was 33 days in the study group and 28 days in the control group,with statistically significant differences(P<0.001).The mean time to milk initiation was 1.5 days in the study group and 1 day in the control group,and the difference between the two groups was not statistically significant(P=0.0058).The duration of complete enteral nutrition was a median of 23 days in the study group and21.5 days in the control group,P=0.073,which was not statistically significant.There was no statistically significant difference between the control and experimental groups in terms of feeding frequency,amount of milk opened,the incidence of NEC,gastrointestinal bleeding,and occurrence of cholestasis(P>0.05).3.Analysis of hypoglycemia and thyroid function status in preterm infants: The incidence of hypoglycemia in the study group was 22.5%(18/80),higher than that in the control group(11/100),and the difference was statistically significant by the analysis of variance(χ2=4.349,P=0.037);the incidence of hypothyroidism in the study group was 37.5%(30/80),higher than that in the control group The incidence was 14.0%(14/100),and the difference was statistically significant by analysis of variance(χ2=13.289,P<0.001).The incidence of metabolic bone disease was 8.0%(8/80)in the study group and 8.0%(8/100)in the control group The difference was not statistically significant by difference analysis(χ2=0.220,P=0.639).Conclusion:1.The incidence of feeding intolerance,hypoglycemia,and transient hypothyroidism was higher in newborns born to HDP mothers at gestational age <32 weeks than in the nonHDP mother group,and the duration of all oral feedings and total hospitalization days were longer.2.Gastrointestinal bleeding,neonatal necrotizing small bowel colitis,metabolic bone disease,and cholestasis in preterm infants with maternal HDP were not significantly associated with maternal HDP. |
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