| Research background:Anal fistula is a common disease in clinical practice,At present,surgery is the best choice to cure this disease.However,the recovery of postoperative wound is a problem that has been discussed by major doctors,Western medicine mainly uses anti-infection to promote wound healing,The postoperative recovery period was longer,The quality of life of patients is affected.Therefore,it is necessary to explore a better method to restore the wound after anal fistula surgery.Traditional Chinese medicine has a superior impact on postoperative wound healing,according to several clinical research.Research objective:To research the effects of shengjiyuhong medicinal gauze and heat resistant moxibustion on healing wounds following anal hernia surgery,To explore whether its combination can accelerate wound healing after anal fistula surgery,The possible adverse events were also observed,The safety was evaluated,To provide a simple,safe and effective method for wound healing after anal fistula surgery.Research method:Patients who satisfied the diagnostic criteria in the anorectal department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine served as the study’s participants,After informing them of the significance of the project,They voluntarily participated in this experiment and signed the informed treatment consent form.A total of 60 patients were included.These 60 patients with post-operative anal fistulas were given numbers and randomly assigned to observation and control groups,each with 30 cases.The observation group used thermal moxibustion combined with gauze change of raw muscle yuhong cream,The control group simply used the gauze of raw muscle yu red ointment for dressing change.Prior to treatment,Postoperative trauma,gender and age were compared between the two groups of patients,After treatment,The postoperative wound healing time,wound healing rate and exudate were compared between the two groups,Record adverse reactions and deal with them in a timely manner,Statistical analysis of all data was performed using SPSS 25.0 statistical software.Research results:(1)The patient’s age,gender,duration of disease and postoperative original wound were compared,There was basically no difference in the condition of the two groups before treatment(P>0.05),Not statistically significant,Comparisons can be made.(2)In terms of pain relief:Intra-group comparison of trauma pain scores in both groups,All gradually decreased after treatment(P <0.05),The difference in pain score comparison results on postoperative day 1 was not significant(P>0.05),And pain scores on postoperative day3 versus day 5,The observation group was significantly lower than the control group(P3,P5 < 0.01),Statistically significant difference in comparison of pain scores on postoperative days 7,10 and 14,The observation group was lower compared to the control group(P<0.05).(3)Traumatic exudate condition:The trauma exudate scores within the two groups were compared,They were all found to decrease after treatment(P<0.05),Comparison of postoperative day 1 scores between the two groups,no significant difference(P>0.05),And on postoperative days 3,5,7,and 10,Observation group scores were lower than the control group(P3,P5,P7,P10<0.05),The score of the observation group was significantly lower than that of the control group on the 14 th postoperative day(P14<0.01),a significant difference.(4)Growth of granulation tissue:There was no significant change in sarcomeres in both groups on postoperative day 3(P>0.05).Postoperative days 7 and 14,The control group scored higher than the observation group(P < 0.05).Post-operative day 21,The observation group scores were significantly lower than the control group(P21<0.01).(5)In terms of trauma area,trauma healing rate:There was no significant difference between the two groups within three day after surgery(P>0.05),There was a significant difference in the comparison between the two groups after one week.The observation group repaired the wounds faster(P<0.05).(6)In terms of wound healing time:The postoperative comparison between the two patient groups revealed a substantial difference.In comparison to the control group,the observation group’s time to complete wound healing was shorter(P<0.05).(7)In terms of inflammatory factor expression levels:Both the observation group and the control group were successful in lowering the levels of TNF-α and IL-6 in the patients’ blood,However,the control group’s rate of decline was significantly slower than that of the observation group(P<0.01),indicating a significant difference between the two groups.(8)In terms of VEGF expression levels in postoperative traumatic granulation tissue:The observation group’s postoperative wounds had greater VEGF levels than the control group’s did(P<0.05).In particular,on the 14 th and 28 th postoperative days,the VEGF levels in the postoperative wounds of the observation group were considerably greater than those of the control group over the same time(P < 0.01),with significant differences.(9)Regarding overall clinical efficacy: The observation group’s effective rate was noticeably greater than that of the control group.There was a statistically significant difference(P<0.05).The results of the study showed that the observation group outperformed the control group in terms of reducing patient pain,reducing traumatic exudate and lowering the level of inflammatory factors,Compared with the control group,the observation group could better promote the growth of wound granulation tissue and accelerate wound healing,Increase traumatic VEGF levels.Conclusion:(1)Thermosensitive moxibustion combined with myogenic yuhong cream for post-operative anal fistula wound repair is effective,It promotes the healing of wounds.(2)Compared to post-operative treatment of anal fistula with raw muscle yuhong cream alone,The combination of thermal moxibustion and Yohong cream group not only heals the wound faster,It is also effective in reducing postoperative inflammatory reactions in patients,Promotes the expression of VEGF production in traumatic granulation tissue with good efficacy and safety. |
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