Clinical Analysis Of Acute Leukemia Inpatient Infection

Purpose: To analyze the characteristics of infection in patients with acute leukemia during hospitalization,in order to provide evidence for reducing the incidence of infection,effective anti-infection,shortening the duration of infection and improving the prognosis of patients with acute leukemia.Method: The infection rate,infection site,distribution of pathogenic bacteria,drug sensitivity of pathogenic bacteria,and influencing factors of fever time during antibiotic use in patients with acute leukemia during hospitalization of 91 patients(299 times)in the First Affiliated Hospital of Dali University from January 2022 to October 2022 were retrospectively analyzed.Results: The overall infection rate of acute leukemia patients during hospitalization was 55.18%.The infection rate of acute myeloid leukemia patients was the highest(57.21%),and the infection rate of acute lymphoblastic leukemia was49.35%.The infection rates in different disease states were newly diagnosed(88.57%),in remission(34.75%),in non-remission(68.63%),and in relapsed/refractory(69.44%).The infection rate of age groups were 18-40 years old(36.54%),40-60 years old(64.44%),t;>60 years old(66.67%).The most common infection site was the respiratory system(62.91%),and the detection rate of pathogenic bacteria was8.09%.Among the detected pathogens,gram-negative bacteria(60.98%)were the most common,mainly Escherichia coli and Klebsiella pneumoniae,and were most sensitive to β-lactam /β-lactamase inhibitors,carbapenems,tigecycline,amikacin,and amikacin.The detection rate of gram-positive bacteria was 29.27%,mainly Staphylococcus.In the analysis of the influencing factors of the antipyretic time of 55 cases of fever patients,it was found that the combination of antibiotics,recurrent fever during hospitalization,and fungal and viral infections were P<0.05.In patients whose fever disappeared within 1 to 3 days,β-lactam / β-lactamase inhibitor was the most common antibiotic used alone,and carbapenem + quinolone was the most common antibiotic used in combinationConclusion:1.Acute leukemia patients had a higher infection rate during hospitalization,and AML patients had a higher infection rate than ALL patients.The most common infection site was respiratory tract,and G-bacteria were the main pathogens.Theinfection rate increases with age;Getting the disease into remission as soon as possible can help reduce infection rates.2.In patients with acute leukemia infection and fever,the combination of antibiotics,repeated fever during hospitalization,and fungal and viral infections will affect the time of antibiotic fever reduction.3.β-lactam / β-lacamidase inhibitors were the preferred antibiotics for acute leukemia fever patients.Carbapenems and quinolones are the most commonly used biantibiotics.