Analysis Of Risk Factors Of Antibiotic-related Diarrhea In Emergency General Ward And Preliminary Discussion Of Pathogenic Bacteria And Prevention And Treatment

BackgroundAntibiotic-associated diarrhea(AAD)is a common complication during using antibiotic,which is also an important cause of diarrhea.Some severe cases can lead to death.The incidence and risk factors of AAD are different associated with regions,hospitals and patient.The purpose of this study is to explore the risk factors of AAD in emergency wards,and to analyse the pathogens and treatment of AAD.MethodThis study is a retrospective study.Patients in the emergency ward of a third-tier A hospital from December 2017 to May 2018 were divided into two groups:AAD group and non-AAD group.The basic information,laboratory examination and treatment of patients were collected,and univariate and logistic regression analysis were carried out for the two groups.Secondly,the pathogen and treatment of AAD were analyzed.ResultA total of 200 patients were enrolled in the study,and 38 patients developed AAD.Univariate analysis showed that hospitalization time,diagnosis,state of consciousness,activated partial thromboplastin time,antibiotic use and intravenous nutrition,proton pump inhibitors,invasive operation,hospitalization time were risk factors for AAD.Logistic regression analysis indicated that infectious diseases,high urea nitrogen level,hospitalization may be independent risk factors for AAD.Clostridium difficile infection rate in AAD was 21%.ConclusionInfectious diseases,high urea nitrogen level,hospitalization may be independent risk factors for antibiotic-related diarrhea in emergency inpatients.Clostridium difficile is still a common pathogen of AAD.