Diagnostic Value Of Interferon-γ Release Assay Combined With C-reactive Protein In Active Pulmonary Tuberculosis

ObjectiveTo study the diagnostic value of interferon-γ release assay combined with C-reactive protein in active pulmonary tuberculosis,and to provide new ideas for early clinical diagnosis of active pulmonary tuberculosis.MethodIn this study,164 patients who were treated in the First Affiliated Hospital of Dali University from January 2019 to December 2022 were selected.According to the final clinical diagnosis criteria,the patients were divided into 78 patients with inactive tuberculosis and 86 patients with active tuberculosis.The general information and laboratory test results of all the subjects were collected and analyzed by statistical software to compare the differences in various indicators between the two groups,and finally explore the diagnostic value of interferon-γ release assay combined with C-reactive protein for active pulmonary tuberculosis.Result1.Comparison between inactive pulmonary tuberculosis group and active pulmonary tuberculosis group:There was no significant difference in general data between the two groups(P>0.05).2.The comparison between the inactive pulmonary tuberculosis group and the active pulmonary tuberculosis group:the positive rate of interferon-γ release test in the active pulmonary tuberculosis group was higher than that in the inactive pulmonary tuberculosis group,but there was no significant difference in the positive rate of interferon-γ release assay between the two groups(P>0.05).3.The positive rate of interferon-γ release assay was significantly higher than that of acid-fast staining microscopy in active tuberculosis group,and the difference between the positive rates of the two detection methods was statistically significant(P<0.05).4.Comparison of laboratory indicators between the inactive pulmonary tuberculosis group and the active pulmonary tuberculosis group:there were no significant differences in the white blood cell count,platelet,hemoglobin,platelet-to-lymphocyte ratio,monocyte-lymphocyte ratio and neutrophil-to-lymphocyte ratio between the two groups(P>0.05).The albumin level of inactive pulmonary tuberculosis group was higher than that of active pulmonary tuberculosis group,while the levels of C-reactive protein and fibrinogen of inactive pulmonary tuberculosis group were lower than those of active pulmonary tuberculosis group,and the difference was statistically significant(P<0.05).5.The ROC curves showed that albumin tuberculosis activity area under the curve is 0.58,is not statistically significant(P>0.05)while the area under the curve of fibrinogen and C-reactive protein for pulmonary tuberculosis activity assessment was0.59 and 0.68,respectively,which was statistically significant(P<0.05).Combined with interferon-γ release assay,the area under the curve of fibrinogen and C-reactive protein in the diagnosis of active pulmonary tuberculosis was 0.67 and 0.74,respectively,with statistical significance(P<0.05).6.The application of binary Logistics regression analysis showed that C-reactive protein was a risk factor for active pulmonary tuberculosis,with statistical significance(P<0.05).Conclusion1.Compared with the inactive pulmonary tuberculosis group,the levels of fibrinogen and C-reactive protein increased,while the level of albumin decreased in the active pulmonary tuberculosis group.2.Compared with the individual indicators,the interferon-γ release assay combined with C-reactive protein detection showed higher diagnostic efficacy for active pulmonary TB.3.The C-reactive protein is a vital risk factor for the occurrence of active pulmonary TB.