To Investigate The Efficacy Of Oral Solution Of Sodium Fructose Diphosphate In Cardiac Exercise Rehabilitation

Objective: Sodium fructose diphosphate is a myocardial energy metabolizing drug,which can affect both aerobic and anaerobic metabolic processes of the body.Exercise training is an important therapeutic means for the rehabilitation of cardiovascular diseases,which can improve the cardiopulmonary function of patients with cardiovascular diseases.This paper discusses whether the combined application of exercise training under the guidance of exercise prescription formulated through cardiopulmonary exercise test and fructose sodium diphosphate has more significant effect on cardiac exercise rehabilitation.Methods: A total of 52 patients who were receiving cardiac rehabilitation treatment in the Cardiac Rehabilitation Center of the Department of Cardiovascular Medicine,Affiliated Hospital of Changchun University of Traditional Chinese Medicine from March 2021 to March 2022,meeting the diagnostic criteria for coronary heart disease but excluding patients with acute myocardial infarction within 15 days,were enrolled in this study.Among them,there were 26 patients in the experimental group and 26 patients in the control group.For the drug treatment of these two groups,the secondary prevention standards of coronary heart disease were followed.The experimental group received rehabilitation training under exercise prescription guidance for 4 weeks,and took 2g sodium fructose diphosphate oral solution three times a day.The control group was not given oral solution of sodium fructose diphosphate and only completed rehabilitation training under the guidance of exercise prescription.All patients underwent cardiopulmonary exercise tests before enrollment to develop a structured exercise prescription.After 4 weeks of intervention,patients in the experimental group and the control group were evaluated before and after intervention.Evaluation indexes of cardiopulmonary exercise before and after intervention were analyzed,including changes in peak oxygen uptake(peak VO2),changes in oxygen uptake at anaerobic threshold(VO2AT),changes in metabolic equivalent(METs),changes in oxygen pulse at anaerobic threshold and changes in peak oxygen pulse,and intra-group comparison and inter-group comparison were conducted respectively.Results: After intervention,the change value of peak oxygen uptake(peak VO2),the change value of oxygen uptake at anaerobic threshold(VO2AT),the change value of metabolic equivalent(METs),the changes in oxygen pulse at anaerobic threshold and the changes in peak oxygen pulse in experimental groups were increased,and the differences were statistically significant(all P<0.05).After intervention,the change value of peak oxygen uptake(peak VO2),the change value of oxygen uptake at anaerobic threshold(VO2AT),the change value of metabolic equivalent(METs),the changes in oxygen pulse at anaerobic threshold and the changes in peak oxygen pulse in control group were increased,and the differences were statistically significant(all P<0.05).After intervention,compared with control group,the change value of peak oxygen uptake(peak VO2),change value of oxygen uptake at anaerobic threshold(VO2AT),change value of metabolic equivalent(METs),changes in oxygen pulse at anaerobic threshold and changes in peak oxygen pulse of experimental group were increased,and the difference of exercise indexes between the two groups after intervention was compared,and the difference of the experimental group was higher than that of the control group,and the differences were statistically significant(all P<0.05).Conclusion:1.Exercise training improved the exercise endurance of patients with coronary heart disease,enabling them to regain a better life.2.Fructose sodium diphosphate combined with exercise rehabilitation can improve exercise endurance more significantly in patients with coronary heart disease.