Clinical Study Of Fuzhengjiannao Ointment On Prevention Of Extensive Stage Small Cell Lung Cancer Brain Metastases Of Qi Deficiency And Phlegm Dampness Syndrome

Objective: This study uses a retrospective historical controlled study method.The purpose of this research was to observe the incidence of Fuzhengjiannao ointment in averting brain metastases in those with qi deficiency and phlegm dampness,a type of extensive stage small cell lung cancer.The aim was to measure the impact of the Fuzhengjiannao ointment on the time of brain metastasis,progression-free survival,safety,and quality of life.Methods: A total of 72 cases of patients with extensive stage small cell lung cancer of qi deficiency and phlegm dampness meeting the inclusion criteria from three internal departments and integrated TCM and western medicine departments of Jilin Cancer Hospital from January 2018 to December 2021.From January 2021 to December 2021,36 patients with extensive stage small cell lung cancer were observed,who had taken Fuzhengjiannao ointment in combination with Western standard treatment.The control group was the electronic medical record system of the consulting department,and the first36 extensive stage small cell lung cancer patients who met the medical discharge criteria admitted to the department from January 2018 to December 2020 were collected in chronological order,using the standard conventional treatment of Western.The conventional treatment of patients in both groups was conducted in accordance with the lung cancer treatment guidelines of the Chinese Society of Clinical Oncology,which was 1 cycle of 21 days and 6 cycles of continuous treatment.The incidence of brain metastasis,progression-free survival,TCM syndrome efficacy,KPS score,quality of life score,and safety observation measures were compared with the two groups.The data results were statistical analyzed using spss26.0 software.Results: Statistical analysis showed that the incidence of brain metastases,time of brain metastases,PFS,curative effect of TCM syndrome,quality of life and NSE level in the observation group were better than those in the control group,the difference was of significance in statistics science(P < 0.05).The toxic and side effects of the patients after treatment in the two groups were similar,mainly including bone marrow suppression,gastrointestinal reaction,liver function impairment,and renal function impairment,with no obvious difference(P>0.05).Conclusion: Fuzhengjiannao ointment combined with standard treatment of Western medicine can reduce the 1-year brain metastasis rate in patients with extensive stage small cell lung cancer,prolong PFS,improve the clinical symptoms of TCM,enhance the quality of life and regulate the level of NSE.The security is good.