Clinical Effect Of Lifestyle Intervention On Metabolic Fatty Liver Disease

Object: To observe the clinical effect of low carbohydrate diet combined with moderate intensity aerobic exercise on metabolic fatty liver disease and related metabolic disorders,and provide theoretical data and new ideas for the prevention and treatment of metabolic fatty liver disease.Methods: 80 patients diagnosed with MAFLD through physical examination or gastroenterology at the First Affiliated Hospital of Shihezi University from October 2021 to October 2022 were selected as the study subjects.They were randomly divided into four groups: low carbon diet+aerobic exercise group(Lch+AEx group),low carbon diet group(Lch group),aerobic exercise group(AEx group),and control group.The intervention time was 6 months.Lch+AEx group adopted low carbohydrate diet+moderate intensity aerobic exercise;Lch group emphasized low carbohydrate diet,and daily activity level remained unchanged;AEx group emphasized moderate intensity aerobic exercise and regular diet;The control group used conventional diet,and the level of daily activities remained unchanged.Baseline data(W,BMI,waist circumference,SBP,DBP),liver function(ALT,AST),uric acid(SUA)and related indicators of glucose and lipid metabolism(TG,TC,LDL-C,HDL-C,FPG,2h PG,Hb A1c)before and after intervention were collected and analyzed.The changes of CAP and LSM of MAFLD patients in each group before and after the intervention were detected by using the Fibroscan equipment of the French Echosens company.Compare the difference between the four groups before and after intervention.Results: 1.The final successful completion of the experiment included 10 participants in the control group,8 participants in the AEx group,15 participants in the Lch group,and 19 participants in the Lch+AEx group.There was no significant difference in age,sex,height,weight,body mass index,waist circumference,systolic blood pressure,diastolic blood pressure,smoking history,drinking history,hypertension history,diabetes history,coronary heart disease history and other basic information of each group(P>0.05).After receiving a low-carbon diet and moderate intensity aerobic exercise,the baseline data(W,BMI,waist circumference,SBP),liver function(ALT,AST),glucose and lipid metabolism related indicators(TG,TC,LDL-C,2h PG),uric acid,CAP,and LSM in the Lch+AEx group were significantly improved compared to before(P<0.05).The baseline data(W,BMI,waist circumference),liver function ALT,blood lipid index TG,CAP,and LSM of the Lch group after receiving low-carbon diet intervention improved compared to before(P<0.05).There was no significant difference in indicators between the AEx group before and after intervention(P>0.05).There was no significant difference in indicators between the control group before and after intervention(P>0.05).3.Select four groups of subjects with significant differences in data before and after intervention for comparison.Using the control group as a reference,the AEx group showed no significant improvement in indicators,while the Lch group showed improvements in ALT and LSM.The Lch+AEx group showed significant improvements in W,BMI,waist circumference,ALT,AST,LDL-C,CAP,and LSM values,with ALT and LSM decreasing more significantly than the Lch group(P<0.05).Taking the AEx group as a reference,the W of the Lch group decreased significantly,while the W,BMI,waist circumference,ALT,AST,LDL-C,and CAP of the Lch+AEx group improved significantly(P<0.05).Compared to the Lch group,the Lch+AEx group showed significant improvements in W,BMI,LDL-C,and CAP(P<0.05).Conclusion: 1.Lifestyle intervention can significantly improve MAFLD and its associated obesity,overweight,hyperlipidemia,hyperuricemia and other chronic metabolic disorders.2.Low-carbon diet can significantly reduce liver fat deposition,liver hardness and liver fibrosis in MAFLD patients.3.The effect of low carbon diet combined with moderate intensity aerobic exercise is more significant than that of simple low carbohydrate diet.