Clinical Observation Of Compound Huangliansu Tablet Combined With Quadruple Therapy In The Treatment Of Refractory HP (Dampness-heat Syndrome Of Spleen And Stomach)

Obcective : In this study,compound Huangliansu tablet combined with standard quadruple therapy was used to treat refractory Helicobacter pylori infection(spleen and stomach dampness-heat syndrome).Compared with single standard quadruple therapy,the eradication rate,improvement of clinical symptoms and adverse reactions of the two treatments were compared,and the efficacy of compound Huangliansu tablet combined with standard quadruple therapy was observed in the treatment of refractory Hp(spleen and stomach dampness-heat syndrome).To explore whether the combination of traditional Chinese and western medicine has advantages in the treatment of refractory Hp.Methods:Seventy-two patients(with damp-heat evidence of spleen and stomach)who had failed standard quadruple therapy three or more times were selected from the outpatient clinic of the Department of Gastroenterology,First People’s Hospital,Yunnan Province,and 36 patients were randomly assigned to each group.Control group: standard quadruple therapy with oral amoxicillin clavulanate potassium,tetracycline,esomeprazole and colloidal bismuth,treatment group: Compound Huangliansu tablets plus standard quadruple therapy with oral compound Huangliansu,amoxicillin clavulanate potassium,tetracycline,esomeprazole and colloidal bismuth,treated for 14 days,14 C breath test was performed again after 1 month of discontinuation,The results,TCM symptom scores,assessment of clinical symptom improvement,and occurrence of adverse reactions were recorded before and after treatment,and the Hp eradication rate,TCM symptom scores,and TCM evidence of efficacy were statistically analysed.Result : After applying different drugs to treat refractory Hp infection in the two groups,the eradication rate of Hp was 88.2% in the treatment group,which was higher than that of 78.7% in the control group,with no statistically significant difference(P>0.05).In evaluating the efficacy of TCM evidence,the overall efficacy rate of 97.06% in the treatment group was higher than that of 87.88% in the control group,with a statistically significant difference(P<0.05).After treatment,in terms of total TCM symptom scores in both groups,the total scores of patients in both groups were lower than before(P < 0.05),and the treatment group had an advantage over the control group when comparing between groups(P < 0.05).In terms of individual TCM symptom scores,the treatment group showed better improvement than the control group in the symptoms of abdominal and epigastric pain,dry mouth,bitter mouth and irritability(P < 0.05),while there was no statistical difference in the symptoms of abdominal and epigastric fullness,thirst without desire to drink,loss of appetite,nausea and vomiting,burning in the stomach and epigastric region,and acidity and belching(P > 0.05).There were no serious adverse events during treatment in either group.Conclusion : The combination of compound huangliansu tablets and standard quadruple therapy is similar to standard quadruple therapy in the treatment of refractory Hp infection(damp-heat evidence in the spleen and stomach)in terms of Hp eradication rate,but it is more advantageous in improving clinical symptoms,and is safe and effective.