Study On The Clinical Efficacy Of Xiaofeng Powder In Treating Atopic Dermatitis Of Wind-heat And Blood-dryness Syndrome

Purpose : To observe the clinical efficacy and safety of Xiaofeng Powder on atopic dermatitis with wind-heat and blood-dryness syndrome.Methods : The selected cases were obtained from outpatients and inpatients of the Department of Dermatology,Kunming Traditional Chinese Medicine Hospital from2021-12-01 to 2022-12-31.The 108 patients with atopic dermatitis of wind-heat and blood-dryness syndrome who met the inclusion criteria were randomly divided into treatment group,control group A and control group B.The treatment group was treated with oral herbal medicine,Xiaofeng Powder and western medicine,Cetirizine Hydrochloride Tablets,control group A was treated with oral western medicine,Cetirizine Hydrochloride Tablets,control group B was treated with oral herbal medicine Xioafeng Powder.The skin lesion score,quality of life score,efficacy and adverse reactions of each patient were observed and recorded before and after 4 weeks of treatment,and a return visit was made 3 months after the end of treatment to record the recurrence,and the data were collated and statistically analysed to draw final conclusions.Results:1.Comparison of therapeutic efficacyAt the end of treatment,the total effective rate of the treatment group(Cetirizine Hydrochloride Tablets and Xiaofeng Powder)was 84.38%,the total effective rate of control group A(Cetirizine Hydrochloride Tablets)was 65.63%,and the total effective rate of control group B(Xiaofeng Powder)was 53.13%.The total effective rate of the treatment group was significantly higher than that of control group A and control group B(P < 0.05),which was statistically significant.It showed that the efficacy of Cetirizine Hydrochloride Tablets combined with Xiaofeng Powder was better than that of Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone in the treatment of atopic dermatitis.There was no significant difference between Control Group A and Control Group B(P >0.05),indicating that the difference in efficacy between Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone was not significant.2.Analysis of skin lesion scoresComparison of SCORAD scores: comparison before and after treatment within the three groups(P<0.05),suggesting that the treatment in all three groups had an improvement effect on the patients’ skin lesions.After 4 weeks of treatment,the comparison between the three groups(P < 0.05),and the comparison between the treatment group and control group A and the treatment group and control group B(P < 0.05),suggested that the treatment effect of Cetirizine Hydrochloride Tablets in combination with Xiaofeng Powder on skin lesions was significantly better than that of Cetirizine Hydrochloride Tablets or Xiaofeng Powder alone.There was no significant difference between control group A and control group B(P > 0.05),indicating that the difference between Cetirizine Hydrochloride Tablets or Xiaofeng Powder alone.3.Quality of Life Index(DLQI)analysisThe comparison of quality of life scores before and after treatment within the three groups(P < 0.05)suggests that the treatment in all three groups improved the quality of life of the patients.After 4 weeks of treatment,the comparison between the three groups(P <0.05)and the two comparisons between the treatment group and control group A,and the treatment group and control group B(P < 0.05).It indicated that the improvement in patients’ quality of life with Cetirizine Hydrochloride Tablets in combination with Xiaofeng Powder was significantly better than that with Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone.There was no significant difference between control group A and control group B(P > 0.05),suggesting that the improvement in patients’ quality of life with cetirizine hydrochloride tablets alone.There was no significant difference between Control Group A and Control Group B,suggesting that there was no significant difference in the improvement of quality of life between Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone.4.Evaluation of adverse reactionsThrough clinical observation,all three groups of patients did not experience any adverse reactions related to the treatment drugs during the treatment period.5.Analysis of recurrence rateWhen the patients were returned 3 months after the end of treatment,the recurrence rate in the treatment group(22.22%)was significantly lower than the recurrence rate in control group A(61.90%)and control group B(53.33%).And by statistical analysis,there was a significant difference between the three groups(P < 0.05).And by pairwise comparison,the treatment group was compared with control group A and the treatment group with control group B(P<0.05).It indicates that the recurrence rate of both Cetirizine Hydrochloride Tablets in combination with Xiaofeng Powder.It was lower than that of Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone.There was no significant difference between control group A and control group B(P>0.05),suggesting that the difference between the recurrence rate of both Cetirizine Hydrochloride Tablets and Xiaofeng Powder alone.Conclusion:1.The combination of Cetirizine Hydrochloride Tablets with Xiaofeng Powder is significantly more effective than single drug in the treatment of atopic dermatitis with wind-heat and blood dryness syndrome,with significant improvement in skin lesions,quality of life,and a significantly lower recurrence rate.2.The difference in efficacy between Cetirizine Hydrochloride Tablets alone and Xiaofeng Powder is not significant,which indirectly indicates that Xiaofeng Powder is clinically effective and has a good safety profile.