| Objective: To reassess the xiaofeng qushi decoction’s clinical efficacy as well as security,investigate the formula’s mechanism of action infinitesimally through changes in serum total Ig E,IL-4,and IFN-γ levels before and after treatment and provide a clinical underpinning for the Chinese medicine diagnosis and treatment of chronic urticaria.Methods: According to the random numbers obtained from the statistical random number table,66 patients with chronic urticaria who were listed by traditional Chinese medicine as having wind-heat with dampness were randomly assigned into a test group and a control group in a 1:1 ratio,with 33 cases in each group.The control group received oral olopatadine hydrochloride tablets,while the experimental company received Xiaofeng Qushi Decoction orally.Patients in both groups completed a course of treatment that spanned four weeks,making a total of two sessions of treatment that were observed.Both groups’ sets of standard,recurrence,risk factors,and modifications in serum total Ig E,IL-4,IFN-γ levels throughout the period prior to and following therapy were assessed.The statistical software Spss26.0 was used to conduct the study and generate the results.Result1.62 legitimate instances were gathered from 66 individuals who received tests,of which 31 cases served as the test group and 31 cases as the control group.The two groups’ baseline data for age,gender,disease duration,clinical symptom score,total serum Ig E,IL-4,and IFN-γ were compared before observation,and no differences all of which were statistically significant(P > 0.05)were identified.2.The test group outperformed than the control group(P <0.05)in terms of both healing and total effective rates at the end of the treatment course: the test group’s healing rate was 54.83% and its total effective rate was 96.77%,while the control group’s healing rate was 29.03% and its total effective rate was 93.55%.3.Clinical symptom scores were statistically significant in the same group throughout the treatment regimen(P < 0.05);statistically significant variations were observed between the groups(P < 0.05);and the experimental group exceeded the control group.Following a technique,the experimental group would have substantial variations from the control group in the duration and magnitude of the itching of the clinical symptoms(P < 0.05),favoring the experimental group.4.The experimental group’s TCM symptom score substantially improved throughout the course of therapy compared to that observed before treatment started(P <0.05).In comparison with the control group’s foundation,there was no considerable improvement(P > 0.05).The distinction between the two categories was statistically significant,and the experimental group outpaced the control group(P < 0.05).5.The DLQI score was clinically meaningful before and following the course in the same group(P <0.05),though there was no clinically substantial distinction among the groups after the course(P > 0.05).6.The difference in total Ig E levels before and after treatment was statistically significant within the same group that completed the course of treatment(P < 0.05).Through all groups,there was no meaningful difference(P > 0.05).7.There were statistically meaningful variations between the serum IL-4 levels within the same group prior to and following the treatment’s conclusion and termination(P < 0.05),whereas there were no statistically significant differences between the groups(P > 0.05).8.Throughout the treatment,serum IFN-γ levels in the same group would dramatically differ from baseline to treatment(P < 0.05),and an intertribal comparison confirmed that the treated group was preferable to the control group(P < 0.05).9.After completing the course of treatment,the experimental group had a significantly lower adverse reaction incidence of 6.45%,while the control group encountered an incidence of 25.81%.This disparity between the two groups was clinically meaningful(P < 0.05).10.At the conclusion of medical treatment,two groups of patients were tracked for three months.In the experimental group,the recurrence rate was 5.88%,comparable to44.44% in the control group.The experimental group’s recurrence rate was markedly lower than the control group’s(P < 0.05).Conclusion: For the treatment of chronic urticaria characterized by the wind-heat-and-dampness syndrome,Xiaofeng Qushi Decoction was far more efficient and effective and had a higher curative rate compared with olopatadine hydrochloride tablets.It also had fewer negative reactions and a lower recurrence rate.It provides high advantages when it comes to enhancing the serum IFN-γ level,clinical symptom score,and TCM symptom score. |
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