Preliminary Study On Risk Factors Of Renal Injury In Patients With Malignant Tumor

Objective: To explore the relationship between malignant tumor and renal injury and the risk factors of renal injury in patients with malignant tumor,so as to help prevent and delay renal injury in patients with tumor.Methods: This study retrospectively collected newly diagnosed patients who were hospitalized in the department of hematology or oncology of our hospital from January 2019 to December 2019 and were diagnosed as hematological and solid malignancies through bone marrow aspiration biopsy or histopathological examination as a case group.The general data,tumor type,or kidney related indicators of the patients were collected.In the case group,the eGFR<90ml/min/1.73 m was tested ~2、 microscopic hematuria 、urinary protein was included as a subgroup of renal injury.At the same time,non tumor patients who matched age and gender and were confirmed to be basically healthy after physical examination were collected as the control group,and general information and renal function related indicators were collected.Compare and analyze whether patients with malignant tumors are more prone to kidney injury than non tumor patients,and which factors are more likely to occur in tumor patients combined with kidney injury.IBM SPSS 26.0 software was used to test the data,and statistical methods such as chi-square test,rank sum test,and analysis of variance were used.Single factor and multivariate logistic regression studies were used to analyze the risk factors of renal injury in patients with malignant tumors.The difference between P<0.05 was statistically significant.Results:1.Compared with the two groups of non tumor patients,there was no difference in gender and age between the two groups(both P>0.05),which was comparable.There were statistically significant differences between the two groups in blood urea,cystatin C,serum creatinine,eGFR,blood uric acid,specific gravity of urine,microscopic hematuria,and urinary protein(P<0.05).This indicates that compared to non tumor populations,patients with malignant tumors have a higher proportion of kidney damage.2.Comparing the three groups of patients with solid malignant tumors,blood malignant tumors,and non tumor populations,the results showed that there was no difference in gender and age among the three groups(all P>0.05),which was comparable.There were statistically significant differences among the three groups in smoking,blood urea,blood creatinine,cystatin C,blood uric acid,eGFR,specific gravity of urine,microscopic hematuria,and urinary protein(P<0.05),hematological malignancies have a higher proportion of kidney damage compared to solid malignancies.3.Patients with malignant tumors were divided into renal injury subgroups and non renal injury subgroups based on whether they were associated with renal injury.A single factor logistic regression analysis was performed.The results showed that there were statistically significant differences between the two groups in age,alcohol consumption,smoking,tumor metastasis,hemoglobin level,and tumor type(P<0.05).The results of multivariate logistic regression analysis showed that the differences in age and smoking between the two groups were still statistically significant(P<0.05).Age(OR=1.044,95% CI 1.018-1.070,P<0.05)and smoking(OR=30.139,95% CI18.303-49.629,P<0.05)were risk factors for renal injury in tumor patients,indicating that the older the age,Patients with smoking habits are more likely to have kidney damage.4.Patients with solid malignant tumors were divided into renal injury subgroups and non renal injury subgroups based on whether they were associated with renal injury,and a single factor logistic regression analysis was performed.The results showed that there were significant differences in smoking history,age,and tumor type between the two groups(P<0.05).The results of multivariate logistic regression analysis showed that there were still statistically significant differences in age,smoking history,and tumor type between the two groups(P<0.05).Age(OR=1.092,95% CI 1.038-1.150,P<0.05),smoking(OR=25.537,95% CI 11.577-56.333,P<0.05),and smoking(OR=25.537,95% CI 11.577-56.333,P<0.05)were risk factors for renal injury in tumor patients,indicating smoking habits Elderly patients with solid malignant tumors of the urinary system are more likely to have kidney damage.5.Patients with hematological malignancies were divided into kidney injury subgroups and non kidney injury subgroups based on whether they were associated with kidney injury.A single factor logistic regression analysis was performed.The results showed that there were statistically significant differences in age,smoking,gender,alcohol consumption,and hemoglobin between the two groups(P<0.05).The results of multivariate logistic regression analysis showed that there were still significant differences in age,smoking,gender,alcohol consumption,and hemoglobin between the two groups(P<0.05),age(OR=1.035,95% CI 1.009-1.061,P<0.05),male(OR=2.026,95% CI 1.083-3.788,P<0.05),smoking(OR=3.468,95% CI1.896-6.344,P<0.05)Drinking alcohol(OR=2.354,95% CI 1.111-4.990,P<0.05)and hemoglobin(OR=0.988,95% CI 0.977-0.998,P<0.05)are risk factors for renal injury in patients with hematological tumors,indicating that hematological malignancies with advanced age,male,smoking habits,drinking habits,and low hemoglobin levels are more likely to develop renal injury.Conclusion:1.Compared to non tumor populations,patients with malignant tumors have a higher proportion of kidney damage,and blood malignant tumors have a higher proportion of combined kidney damage compared to solid tumors.2.Patients with malignant tumors who are older and have a smoking habit are more likely to have kidney damage;Patients with solid malignant tumors who have smoking habits,are older,and have malignant tumors of the urinary system are more likely to have kidney damage;Patients with blood malignancies who are male,older,and have a habit of smoking and drinking are more likely to have kidney damage.3.Male,older age,smoking,drinking habits,low hemoglobin levels,and tumor type may be risk factors for kidney damage in patients with malignant tumors.