Analysis Of Risk Factors Of Acute Attack In Children With Bronchial Asthma Induced By Mycoplasma Pneumoniae Infection

Objective: To explore the risk factors of acute attack in children with bronchial asthma induced by mycoplasma pneumoniae(MP)infection,and to find theoretical basis for prevention of acute attack in children with bronchial asthma.Methods: A retrospective analysis was made of 106 children with acute attack of bronchial asthma who were diagnosed with MP infection in the outpatient department of pediatric respiratory medicine and inpatients of Shengjing Hospital affiliated to China Medical University from October 2016 to December 2021.105 children with not attack of bronchial asthma who were diagnosed with MP infection in the outpatient department during the same period were selected and divided into acute attack group and non-acute attack group of bronchial asthma.The general characteristics,clinical data(clinical characteristics,laboratory examination,lung imaging)of the two groups of children were analyzed by univariate analysis,and the factors with statistical differences in clinical data were analyzed by multivariate logistic regression to find the risk factors of acute attack in children with bronchial asthma infected by MP.Results: The univariate analysis of the clinical data of children in acute attack group and non-acute attack group showed that there was no significant difference in age,sex,weight and region between children in acute attack group and children in non-acute attack group(P>0.05);The proportion of children in the acute attack group who avoided allergens and the proportion of children who regularly inhaled glucocorticoids(ICS)were significantly lower than those in the non-acute attack group(P<0.05);There was no significant difference between the two groups in the proportion of children with severe cough,the proportion of children with family history of bronchial asthma and the number of years of diagnosis of bronchial asthma(P>0.05).Laboratory examination: the proportion of children with other pathogenic infections was significantly different between the two groups(P<0.05);There was no significant difference between the two groups in white blood cell,eosinophil count,total immunoglobulin E,C-reactive protein,calcitonin,lactate dehydrogenase and alanine aminotransferase levels(P>0.05).Pulmonary imaging: there was no significant difference between the two groups in the proportion of children with small airway changes,the proportion of children with multiple lung lobe involvement(≥3),the proportion of children with lobar pneumonia,and the proportion of children with pleural effusion(P>0.05).Multivariate logistic regression analysis showed that the risk factors of acute attack in children with bronchial asthma caused by mycoplasma pneumoniae infection.The results showed that regular ICS treatment(P<0.05,OR=0.413,95%CI=0.231～0.738)was the protective factor of acute attack in children with bronchial asthma caused by mycoplasma pneumoniae infection.Conclusion: Regular ICS treatment is a protective factor for acute attack of children with bronchial asthma induced by MP infection.Regular nebulization can prevent acute attack of children with bronchial asthma induced by MP infection.