Predictive Value Of The HCT-CI And The EBMT Risk Score For Non-relapse Mortality In A Population Of Patients Undergoing RIC-haplo-HDPSCT

Objective:To investigate the predictive value of the hematopoietic cell transplantation comorbidity index(HCT-CI)and the European Group for Blood and Marrow Transplantation(EBMT)risk score for non-relapse mortality(NRM)after reduced intensity conditioning haploidentical high-dose peripheral blood stem cell transplantation(RIC-haplo-HDPSCT).Methods:51 received RIC-haplo-HDPSCT recipients were selected as the research subjects.According to whether there was non-relapse mortality after RIC-haplo-HDPSCT,they were divided into NRM group(n=14)and non-NRM group(n=37).The general data,HCT-CI,EBMT score were compared between the two groups.Results:The HCT-CI,EBMT scores was higher in the NRM group than those in the non-NRM group(P<0.05).Kaplan-Meier survival analysis suggested that there were statistical differences in the survival distribution of patients with different levels of HCT-CI and EBMT scores(log rank test:x~2=19.385,6.714,respectively,P<0.05).Spearman rank correlation analysis shows that there was a positive correlation between HCT-CI(r=0.548),EBMT score(r=0.440)and the incidence of NRM after RIC-haplo-HDPSCT(P<0.05).Logistic regression analysis showed that EBMT score(OR=5.032)and HCT-CI(OR=9.478)were independent influencing factors of NRM after RIC-haplo-HDPSCT(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of HCT-CI and EBMT score in predicting NRM after RIC-haplo-HDPSCT was 0.749 and 0.768.The combination of HCT-CIandEBMTscorehadthehighestpredictive efficiency(AUC=0.806).Conclusion:The combination of HCT-CI and EBMT scores to predict NRM after RIC-haplo-HDPSCT was higher than each application alone,and HCT-CI and EBMT scores were independent risk factors for NRM.