Association Between Sarcopenia And Fatty Liver In Middle-aged And Elderly Patients With Type 2 Diabetes Mellitus

Objective:This study investigates the correlation between the production of sarcopenia and fatty liver in middle-aged and elderly type 2 diabetic patients through the detection,collection and statistics of muscle content and liver ultrasound,and provides a theoretical basis for the prevention and treatment of T2 DM complications.Methods:A total of 282 T2 DM patients aged 50 years and older admitted to the Department of Endocrinology,First Affiliated Hospital of New Medical University from January 2022 to January 2023 were selected.The body mass index,limb and trunk muscle content of the study subjects were measured using the Bayside Bess In Body body composition analyzer,and the testing method was the bioelectrical resistance method,all subjects were tested and data were collected,and the The results were grouped according to the diagnostic criteria for sarcopenia,and all subjects could be divided according to the grouping criteria into a sarcopenic group/case group(61 cases)and a non-sarcopenic group/control group(221 cases),both groups received the same relevant physical and laboratory examinations,and the results were analysed statistically to investigate the correlation between the development of sarcopenia and fatty liver in middle-aged and elderly patients with type 2diabetes.Results:The differences between the two groups were statistically significant in terms of gender,BMI,prevalence of fatty liver,uric acid,glutathione,blood glucose,lipid-related indicators and skeletal muscle content of the limbs,but not in terms of age,duration of disease,whether or not they had hypertension,whether or not they smoked and whether or not they drank alcohol.a positive correlation was found between BMI,uric acid,fasting C-peptide and ASMI,and after multi-factor Logistic regression analysis revealed that higher levels of BMI,ASMI and uric acid levels were protective factors for sarcopenia.Conclusion:Higher levels of BMI,ASMI and uric acid reduced the incidence of sarcopenia,i.e.high BMI,ASMI and uric acid significantly reduced skeletal muscle atrophy in diabetic patients.With regard to the incidence of sarcopenia,the incidence was lower in the group with fatty liver than in the group without fatty liver,and it can be hypothesized that in the diabetic population,patients with fatty liver are less likely to develop sarcopenia,but there is no evidence to suggest whether fatty liver is a protective or risk factor for sarcopenia.