Distribution Characteristics Of TCM Syndrome Elements And Differences Of Urine AQPs And Urinary Microalbumin In 90 Patients With COPD With "Fast" And "Slow" Phenotype

Objective:To observe the obstructive pulmonary tests（liver function,kidney function,blood gas analysis,urinalysis,lung function）in patients with Chronic obstructive pulmonary disease（COPD）based on the obstructive obstructive pulmonary disease theory.Differences in urinary AQPs and urinary microalbumin indexes as well as distribution rules of TCM syndrome elements were investigated to explore the differences in TCM syndrome elements distribution characteristics and water-liquid metabolic indicators in patients with different phenotypes of COPD.Thus,the water-liquid metabolism characteristics of COPD patients with"fast"and"slow"phenotypes were analyzed.Methods:Baseline characteristics,test results,lung function,TCM syndrome type and syndrome element distribution of COPD patients with different phenotypes were collected during hospitalization in the Fourth Clinical College of Xinjiang Medical University from January 2019 to January 2023,and classified and statistically analyzed.Results:There were 30 cases in each of the"fast","slow"and common groups with COPD,and there was no statistical significance in gender,age or ethnicity among the groups（（49）>0.05）.There was a positive correlation between AQP2and Pa O₂and Sa O₂in the"fast","slow"and common groups（（49）<0.05）.m-Alb was negatively correlated with FEV1/FVC,FEV1%pre and PH（（49）<0.05）,and positively correlated with Pa O₂（（49）<0.05）.TCM syndrome elements were compared between COPD group,"fast"group and"slow"group,and there was no statistical significance among the three groups（（49）>0.05）.Conclusion:There are certain differences in AQPs and urinary microalbumin indexes in patients with COPD with"fast"and"slow"phenotype,suggesting that kidney function has been affected.The water-fluid metabolism indexes related to the kidney can simply reflect the difference between the"fast"and"slow"phenotypes of COPD.There was no significant difference in TCM syndrome elements of different phenotypes of COPD patients,but the basic syndrome elements were mainly phlegm turbidity,phlegm stasis and qi deficiency.