Effect Of Jieyu Tianxiangdan On 5-HT And NE In Patients With Coronary Heart Disease And Anxiety Disorder

Objective:The purpose of this study was to assess the alteration of 5-HT and NE in individuals with coronary heart disease and anxiety disorder who had undergone the Jieyu Tianxiangdan.Method:60 individuals who met the criteria were randomly split into two groups(control group of 30 cases and experimental group of 30 cases).The control group was administered conventional western medicine,and the experimental group used Jieyu Tianxiang Dan in combination with coronary heart disease drugs.After four weeks of treatment,observe the two groups before and after treatment,including the Hamilton anxiety scale(HAMA),Traditional Chinese medicine syndrome score(TCMSS),Quality of life assessment scale(WHOQOL-BREF),and changes in serum 5-hydroxytryptamine(5-HT)and Norepinephrine(NE).SPSS26.0 was used for statistical analysis,and P<0.05 was considered statistically significant.Results:(1)Both groups of patients showed improvement in chest pain symptoms compared to before treatment(P<0.05),while the experimental group showed improvement in symptoms such as sighing,poor sleep,chest pain,and palpitations compared to before treatment.No significant changes were observed in other indicators compared to before treatment(P>0.05).After two groups of treatment,the experimental group showed more significant improvement in symptoms such as chest pain,sighs,and poor sleep compared to the control group(P<0.05),in terms of other symptoms,there was no significant statistical difference between the groups(P>0.05).(2)After both groups of treatment,there was a decrease in TCMSS,the scores of HAMA and WHOQOL-BREF were significantly improved compared to before treatment within the group(P <0.05),the experimental group showed more significant improvement in TCMSS compared to the control group during the same period(P<0.05).However,there was no significant statistical difference in HAMA and WHOQOL-BREF scores between the experimental group and the control group during the same period(P>0.05).(3)There was no significant statistical difference in the distribution of efficacy between the two groups after treatment(P>0.05).Although the experimental group had a clinical total effective rate of 83.33% higher than the control group of 70.00%,there was no significant statistical difference between the two groups(P>0.05).After treatment,the serum 5-HT and NE levels in both groups were better than before treatment(P<0.05),and there was no significant difference between the two groups.There were no adverse reactions in either group(P>0.05).Conclusion:Jieyu Tianxiangdan is effective in treating patients with coronary heart disease and anxiety disorder.It has a significant effect on improving their anxiety,clinical symptoms of traditional Chinese medicine,and quality of life.There are no significant side effects during the medication process,and it is worth widely using in clinical treatment.