| Objective:To observe the clinical efficacy and safety of anthelmintic injection on stable vitiligo.METHODS:A total of 203 patients with stable vitiligo of different evidence types in Uyghur medicine who were hospitalized and gave informed consent in the dermatology departments of various hospitals in Uyghur Autonomous Region,Kashgar Regional Uyghur Medical Hospital and Shache County Uyghur Medical Hospital from September 2020 to January 2023 were selected.The subtypes of abnormal mucus were divided into 6 groups according to the subtypes of abnormal mucus in VMC,namely sweet mucus type(31 cases),salty mucus type(35 cases),sour mucus type(30cases),astringent mucus type(33 cases),tasteless mucus type(34 cases)and plaster-like mucus type(40 cases).All six groups of patients were treated with oral vitamins,topical medication and ultraviolet radiation with the addition of expelled insecticide injection at the same time,and the number of treatment days was 35±5 days.Before and after treatment,we observed the vitamin evidence score,the area of white spots and pigment regeneration,physicochemical indexes,and adverse reactions.Data were compared before and after treatment efficacy using SPSS26.0 statistical software.RESULTS:1)The comparison of general data such as gender,age,disease duration and pre-treatment white spot area and total pigmented spot area among the six groups was not statistically significant(P>0.05)and was comparable.2)The adjuvant treatment of repellent spotted chrysanthemum injection is effective in reducing the area of white spots or even disappearing after different types of stable vitiligo patients,and promoting the regeneration of melanin at the white spots.It has better therapeutic effect on the efficacy of white spot area,the efficacy of regenerated pigment area and the total efficacy of vitiligo.3)There was no significant difference in the efficacy of white spot area,the efficacy of regenerated pigment area,and the total efficacy of vitiligo among different age groups of 203 patients(P>0.05).However,there was a difference between the age group 50-65 years and other age groups(P<0.05).There was no significant difference in the efficacy of vitiligo area between the different disease courses(P>0.05),while there was a significant difference in the efficacy of vitiligo regenerated pigment area and total vitiligo efficacy between the different disease courses(P<0.05).4)Comparison of the total area of pigmented spots after treatment showed a significant difference between the six groups(Z=20.779,P=0.001<0.05).A two-by-two comparison showed that it was statistically significant(P<0.05)between the groups of astringent mucus-sweet mucus and astringent mucus-acidic mucus.5)Within-group comparison of total white spot area before and after treatment was significantly different in the sweet mucinous,sour mucinous,odorless mucinous,and plaster-like mucinous groups(P<0.05).There was no significant difference in the white spot area before and after treatment in the astringent mucus and salty mucus groups(P>0.05).When comparing between groups after treatment,there was a significant difference in white spot area between the six groups(Z=12.560,P=0.028<0.05).A two-by-two comparison showed significant differences(P<0.05)between the groups of sour mucus-acrid mucus and sweet mucus-acrid mucus.6)Comparison of efficacy of vitiligo area:among 203 vitiligo patients who completed the clinical trial,there were 32 patients with healed vitiligo area,84 cases with significant effect,77 cases with effective effect and 10 cases with ineffective effect.The healing rate,apparent effect rate and effective rate were 15.8%,57.2%and 95.1%respectively.The difference in efficacy of white spot area between the 6 groups was statistically significant(?~2=31.873,P<0.001<0.05).A two-by-two comparison showed that it was statistically significant(P<0.05)between the groups of sour mucus-salty mucus and sour mucus-no taste mucus.7)Comparison of the efficacy of regenerating pigmented area,8 cases were cured,54 cases were effective,65 cases were effective,and 76 cases were ineffective among 203 patients.The healing rate,apparent effect rate and effective rate were 3.9%,30.5%and 62.6%,respectively.The differences were statistically significant when comparing the efficacy of regenerating pigmented area in the six groups(?~2=55.733,P<0.001<0.05).A two-by-two comparison showed that it was statistically significant(P<0.05)between the groups of tasteless mucus-sweet mucus and tasteless mucus-salty mucus.8)Among the total efficacy of vitiligo in 203 patients,31 cases were cured,89cases were apparently effective,80 cases were effective,and 3 cases were ineffective.The healing rate,apparent effect rate and effective rate were 15.3%,59.1%and 98.5%respectively.The difference between the total efficacy of vitiligo in the six groups was statistically significant(?~2=28.077,P=0.021<0.05).A two-by-two comparison showed that it was statistically significant(P<0.05)between the groups of sweet mucus-salty mucus and sweet mucus-no taste mucus.9)Among all physicochemical indices before and after treatment compared in 203 patients,the indices with differences were PLT,ALT,BUN,Cr,FT4,and TSH(P<0.05),and the differences of other indices were not statistically significant(P>0.05).10)There were a total of 5 patients with minor adverse reactions and no serious adverse reactions during the whole treatment process.Conclusion:1)The efficacy of repellent mucilaginous injection adjuvant treatment is poor in patients in the age group of 50-65 years,while the efficacy is best in patients with disease duration of 1<～≥5 years.2)Repellent mucilaginous injection adjuvant treatment for patients with sweet mucilaginous,acidic mucilaginous,and plaster-like mucilaginous type has a better effect of promoting regenerative pigmentation and significantly reducing the area of white spots.3)Repellent mucilaginous injection adjuvant treatment for patients with acidic mucilaginous type has the vitiligo with the best total efficacy. |
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