Analysis Of Risk Factors Of Diabetic Kidney Disease In Type 2 Diabetics

Objective Type 2 diabetes is a chronic disease with a variety of causes.The prevalence of type 2 diabetes is increasing worldwide,with an estimated 439 million people living with diabetes worldwide by 2030.Diabetic kidney disease(DKD),as one of the common microvascular complications in patients with diabetes,has become the main cause of end-stage renal disease.As the number of patients with DKD continues to increase,their quality of life continues to decline.It is very important to identify risk factors related to DKD in patients with type 2 diabetes,and to strengthen treatment and change early.Therefore,this study aims to analyze the risk factors of DKD in patients with type 2 diabetes by collecting relevant data of hospitalized patients with type 2diabetes and patients with diabetes.Method The clinical data of 248 patients with type 2 diabetes who were hospitalized in the Department of Endocrinology of Anhui Provincial Hospital from May 2020 to February 2022 were collected.According to urine albumin to creatinine ratio(UACR)or estimated glomerular filtration rate(e GFR),they were divided into diabetic controi group(C group,68 cases)and DKD group(180 cases).The age,duration of diabetes,height,weight,body mass index(BMI),history of hypertension,smoking history,and type 2 diabetes treatment of each group were collected,and fasting venous blood was drawn from the patients on the next morning after admission to detect renal function,blood glucose,Hb A1 c and blood lipids,etc.The general information and laboratory indicators of the two groups were compared,and the data of this study were analyzed by using SPSS 26.0 statistical software.Results(1)Comparison of data between the two groups: Compared with group C,there were statistically significant differences in age,duration of diabetes,hypertension,smoking history,Hb Alc,LDL-C,HDL-C,blood urea nitrogen(BUN),and whether insulin was used to control blood sugar in the DKD group(all P<0.05),there was no significant difference between the two groups in BMI,TG,TC,fasting blood glucose(FBG)and VLDL-C(P>0.05).(2)Taking each index as the independent variable for Spearman correlation analysis,DKD was correlated with age,history of hypertension,smoking,course of diabetes,urea nitrogen,Hb Alc,use of insulin to control blood glucose,LDL-Cand HDL-C(p<0.05).DKD was positively correlated with age,history of hypertension,smoking,course of diabetes,urea nitrogen,Hb Alc,LDL-C,and use of insulin to control blood glucose(r>0),and negatively correlated with HDL-C(r<0).(3)Logistic regression analysis results show that advanced age(≥50 years old),long duration of diabetes(≥10 years),history of hypertension,smoking history,Hb Alc(≥8.5%),blood urea nitrogen(≥7.14 mmol /L),LDL-C(≥3.37 mmol /L),type 2 diabetes patients using insulin to control blood sugar were risk factors for DKD in hospitalized patients with type 2 diabetes(OR values ?were 3.5,3.714,2.995,2.764,3.293,4.366,1.783,4.085,all>1.00,P< 0.05);HDL-C(≥1mmol/L)was a protective factor affecting DKD in patients with type 2 diabetes(OR value<1,P<0.05).Conclusion Higher HDL-C is the protective factor for DKD in hospitalized patients with type 2 diabetes;advanced age,long duration of diabetes,higher Hb Alc,elevated LDL-C,elevated BUN,history of hypertension,smoking and insulin treatment are risk factors for DKD in hospitalized patients with type 2 diabetes independent risk factors.Clinically,early monitoring and management of the above risk factors for DKD has certain value in improving the prognosis of patients with diabetic nephropathy.