Clinical Observation Of Anal Fissure Resection Mucosal Flap Displacement Combined With Moist Exposed Burn Ointment (MEBO) In The Treatment Of Chronic Anal Fissure

Objective:This study aims to observe the clinical efficacy of fissure resection mucosal flap removal combined with wet burn cream in the treatment of chronic fissure,and to compare it with traditional fissure resection combined with wet burn cream to explore the safety and feasibility of fissure resection mucosal flap removal combined with wet burn cream in the treatment of chronic fissure,so as to provide a basis for clinical application and new treatment ideas.Methods:Patients suffering from chronic fissures admitted to the Proctology Division of the Affiliated Healthcare facility of Chengde Medical University from December 2021 to November 2022 who complied with the inclusion criteria and also consented to authorize the informed approval form of the medical trial were randomly split into 35 instances in the therapy team(fissure resection mucosal flap extension combined with wet burn cream)and also control team(fissure resection combined with wet burn cream).The Dutch MMS high-resolution anorectal motility analyzer was used to determine the resting pressure of the two groups before and after surgery.Visual analogue scores(VAS)of pain in the two groups on the 2nd,4th,and 7th days before and after surgery were recorded.postoperative adverse events(wound infection,bleeding,swelling,fecal incontinence,recurrence of fissure within 3 months postoperative);Wound healing within 15 days after treatment.Results:1.The VAS in the treatment group was significantly lower than that in the control group at 2,4 and 7 days post-surgery(P<0.05),and the discrepancy was statistically remarkable(see Table 4 for details).Moreover,the VAS on the second postoperative day after the operation in the treatment group and the control group was significantly decreased in comparison to pre-surgery,the 4th postoperative day compared with the postoperative day 2 and the postoperative day 7(P<0.05),and the difference was statistically significant(see Table 5 and Table 6 for details).2.The postoperative resting pressure in the treatment group and the control group was significantly lower than that before surgery(P<0.01),which was statistically significant(see Table 7 for details).The resting pressure after the operation in the treatment group was substantially diminished compared to the control group(P<0.01),and there was a significant statistical difference(see Table 7 for details).3.The rate of recovery from the injury within 15 days after surgery in the control group was conspicuously higher than that in the experimental group(P<0.01),and the difference was statistically significant(see Table 8 for details).4.Comparison of adverse reaction events between the two groups(P>0.05),there was no statistical difference(see Table 9 for details).Conclusions:1.fissure resection andfissure resection mucosal flap extension can effectively relieve the pain of patients with chronic fissure,and the more obvious the pain relief effect is with the passage of treatment time.fissure resection mucosal flap vanity is significantly superior to fissure resection in relieving pain in patients with chronic fissure.2.fissure resection and fissurectomy mucosal flap removal can effectively reduce the resting pressure of the canal in patients with chronic fissure,thereby alleviating the spasm of the internal sphincter.fissure resection mucosal flap displacement is significantly superior to fissure resection in reducing resting pressure in patients with chronic fissure.3.Patients with chronic fissure who undergo fissure resection have significantly shorter wound healing time than patients who undergo fissure resection,which is significantly better than fissure resection in promoting postoperative wound healing in patients with chronic fissure.4.fissure resection and fissure resection mucosal flap removal are relatively safe surgical methods,but there were no adverse events in the treatment group of fissure resection mucosal flap removal combined with wet burn cream,and its safety and long-term efficacy were speculated to be higher than those of fissure resection combined with wet burn cream control group.In summary,the efficacy of fissure resection mucosal flap removal combined with wet burn cream in the treatment of patients with chronic fissure was significantly better than that of fissure resection combined with wet burn ointment,and the postoperative patients had less pain,faster recovery of function,and higher safety,which is worthy of clinical promotion and application.