| Objective: This study is to evaluate the clinical effect of Quyu Decoction on the prognosis of patients with non-small cell lung cancer(NSCLC-in stage IIIB-IV by investigating and analyzing the changes of laboratory indexes-such as fibrinogen(FIB),D-dimer(D-D),platelet(PLT)-TCM syndrome score and quality of life(QOL).Study methods and contents: On the principle of Randomized controlled trial,Patients with non-small cell lung cancer(NSCLC)of stage IIIB-IV who had not undergone surgical treatment in the First Department of Respiratory Medicine of Lu ’an City Hospital of Traditional Chinese Medicine from October 2020 to July 2022 were selected.According to the criteria of diagnosis,inclusion,exclusion and exclusion,60 eligible persons were selected to join the group,Samples were selected by random number table method,30 cases in the observation group and 30 cases in the control group.The patients in both groups were treated with standard chemotherapy,while the patients in the observation group were treated with modified Quyu decoction on the basis of chemotherapy in the control group 。 the two groups of patients are given standard chemotherapy schemes during the study;the observation group is given modified Quyu Decoction based on syndrome differentiation on the basis of the chemotherapy of the control group,the two groups of patients take the standard chemotherapy time of 21 days as one cycle,and the treatment course is four cycles totaling 84 days,the control group is given chemotherapy for four times within 84 days,The observation group was given Quyu Decoction on the basis of chemotherapy within 84 days.At the end of the whole course of treatment,the changes of coagulation indicators,including fibrinogen(FIB),D-dimer(D-D)and platelet(PLT)clinical indicators,as well as the improvement of prognosis and safety evaluation of TCM syndrome score and quality of life score(QOL)of lung cancer patients were compared between the two groups before and after treatment.These observations were analyzed using spss 26.0.Research results:1.There was no statistical difference in general data between the two groups before formal enrollment,general information included sex,age,pathological type,and disease stage,and there was no significant difference in coagulation index,TCM syndrome score and quality of life(Qol)between the two groups(P>0.05).2.Clotting index:(1)FIB: At the end of the course,comparisons between the groups led to the conclusion that: Observation group on the basis of chemotherapy after taking quyu decoction and control group decreased significantly(P<0.05),after treatment,the FIB in the observation group decreased significantly compared with that before treatment,with a statistical difference(P<0.05),The FIB value of the control group after routine chemotherapy was not significantly lower than that before treatment,showing no statistical difference(p = 0.097).(2)D-D: after the whole course of treatment,the D-D value in the observation group was significantly lower than that in the control group(P<0.05),after the treatment with Quyu decoction,the D-D value in the observation group was significantly lower than that in the control group(P<0.05),after treatment,the D-D value in the observation group was significantly lower than that before treatment(P<0.05),while in the control group,the D-D value after routine chemotherapy was not significantly lower than that before treatment,showing no statistical difference(p = 0.338).(3)PLT: after the whole course of treatment,compared with the control group,the PLT value of the observation group was obviously decreased after taking quyu decoction on the basis of chemotherapy,showing a statistical difference(P<0.05),after treatment,the PLT value of the observation group was significantly lower than that before treatment(P<0.05),while that of the control group after routine chemotherapy was not significantly lower than that before treatment,showing no statistical difference(p =0.837).3.Prognostic indicators:(1)Improvement of TCM syndrome(TCM syndrome score of lung cancer patients):At the end of the course,after treatment with traditional Chinese medicine,the score of TCM syndrome in the observation group decreased significantly compared with that in the control group(P<0.01),and the total score of the observation group after treatment decreased significantly compared with before treatment(P<0.01),no significant changes were observed in the control group(P=0.205).In addition,in the efficacy grade,the observation group had a remarkable effect and the effective rate reached 93%,and the observation group performed excellent(P<0.01).(2)The improvement of quality of life(QOL score)of lung cancer patients: At the end of the course,the QOL score of the observation group was much higher than that of the control group(P<0.01),the total score of the observation group after treatment was significantly higher than that before treatment(P<0.01),while the control group had almost no change(P=0.399).In addition,in the efficacy grade,it can be seen that the observation group improved significantly and performed well(P<0.01).4.Safety evaluation: In this clinical study,there were no adverse events or toxic side effects and adverse reactions directly related to medication.Conclusion: The traditional Chinese medicine decoction Quyu Decoction has good curative effect and improvement on blood hypercoagulability of patients with stage IIIB-IV non-small cell lung cancer,can reduce related TCM syndromes,effectively improve the quality of life and improve the prognosis of tumor patients. |
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