Clinical Application Value Of Using Carbon Nanoparticles Combined With Ex Vitro Lymph Node Sorting After Radical Resection Of Colorectal Cancer

Objective:As a lymph node tracer,nano-carbon has been proved to be safe and effective in clinical work,and has been extensively adopted in various neoplasm.This paper focuses on the practical role of nano-carbon in ex vitro lymph node sorting after radical resection of colorectal cancer,and provides evidence for the feasibility of the combined application of nano-carbon staining and ex vitro lymph node sorting after radical resection.Method:The clinical data of 100 patients with colorectal cancer admitted to our hospital from 2021 to 2022 were enrolled in the study.The patients were divided into two groups according to whether they were labeled with nano-carbon under colonoscopy before operation:nano-carbon group and control group,50 cases in each group.Summarize patients’ basic data(gender,age,height,weight and whether it is complicated with basic diseases),operation-related data(operation mode,operation time,intraoperative bleeding,surgical resection range,etc.),tumor pathological data(differentiation degree,clinical stage,whether it invades vessels and nerves)and postoperative clinical data(drainage tube removal time,total hospital days,postoperative complications,etc.),The data of the above two groups were statistically analyzed to identify whether there were statistical differences between the two groups.Results:In the matter of the sum of lymph nodes harvested after radical surgery was 1536(30.72 ± 10.708)in the nano-carbon group and 1162(23.24 ± 10.476)in the control group;In the matter of the sum of negative lymph nodes harvested after radical surgery was 28.82 ± 10.877 in the nano-carbon group and 21.68 ± 10.800 in the control group.There was a statistical difference between the two groups in the above two data.However,there was no statistically significant difference between the two groups in the basic data of patients(gender,age,height,weight,and whether there was a basic disease)and the pathological data of tumors(degree of differentiation,clinical stage,whether there was vascular and nerve invasion).The amount of intraoperative bleeding was 164.00 ±55.75 ml in the nano-carbon group and 231.43 ± 201.15 ml in the control group;The total number of metastatic lymph nodes detected was 1.90 ±5.092 in the nano-carbon group and 1.56 ± 2.589 in the control group;The extubation time of patients after operation was 6.24 ± 2.227 days in the nano-carbon group and 6.62 ± 1.958 days in the control group;The total hospitalization days of patients were 15.58 ± 5.555 days in the nano-carbon group and 16.22 ± 7.421 days in the control group;In terms of the incidence of postoperative complications,17 patients in the nano-carbon group had complications,while 20 patients in the control group had complications;The operation time was 164.66 ± 41.544 min in the nano-carbon group and 179.94 ± 49.679 min in the control group.There was no statistical difference between the two groups in the comparison of the above data.Conclusions:1.Primary focus labeled with nano-carbon before radical resection combined with ex vitro lymph node sorting can conspicuously improve lymph node detection rate,get more accurate pathological staging and avoid staging migration,enable some patients to obtain more accurate and reasonable post-operative adjuvant treatment,improve the prognosis of patients,and extend their survival.2.Because of its good tendency to the lymphatic system,nano-carbon makes the operator more clear and convenient in determining the extent of radical resection and regional lymph node dissection,lowers the degree of difficulty of lymph node dissection and the occurrence of subsidiary-injury,and benefits patients.3.Some patients can also reexamine the whole colon and resect the scattered polyps to achieve the therapeutic effect.