Correlation Between Intestinal Flora And Short-chain Fatty Acids And Metabolic Syndrome Combined With Coronary Heart Disease

Research ObjectiveApply the 16 SRDNA gene sequencing method and liquid chromatoplapse spectrum combination method to detect patients with metabolic syndrome,metabolic syndrome combined with coronary heart disease,and intestinal flora and short-chain fatty acids of healthy people.The characteristics of changes are discussed to explore the correlation between intestinal flora,SCAFS and metabolic syndrome and coronary heart disease,provide new ideas for alleviating metabolic syndrome,and provide new targets for improving coronary arteriosclerosis.MethodsThis study continuously included in 78 patients who were hospitalize in our hospital in parallel coronary angiography in our hospital.Control group(n= 20),MS group(n = 20),and MS merged CHD group(n = 38)for collection of feces and serum specimens.User use to determine the component and content of patients serum SCAFS.Statistically analyze the testing indicators of each group,compare the differences between intestinal flora and SCAFS in the group,and analyze the association between intestinal flora and SCAFs and metabolic syndrome.Results1.Intestinal flora:Comparison with the MS group in the Control group,the average relative comparative abundance of the dwilobacterium mobilizes and germination of the Control group increased significantly(P<0.05);The average relative abundance of the purpose of Meterobacterium increases significantly(P<0.05),and the average relative abundance of the Prederobacteria in the MS combination and the CHD group increases significantly(P<0.05);The average relative abundance of Bacteroides_plebeius increased significantly(P<0.05).2.Analysis of enterococcal LEFSE:The main characteristic flora of the Control group is Bisidobacteria,Bisidobacterium,Bisotramia,Bacteria,Bacterium,and Bacteria;Germany,Bask bacteria,and hemobacteria;the main characteristic flora of MS combined with the CHD group is ε deformed bacteria,bending bacteria,and curve.3.Serum SCAFS:MS groups,antidine,beextine,and total SCAFS concentration are significantly higher than that of the Control group(P<0.05).The concentration of isopic acid in the MS combined CHD group is compared to the Control group(P<0.05)significantly increased,and the concentration of 7 SCAFS and total SCAFS in the MS merged CHD group was similar to that of the MS group,and there was no statistical difference(P> 0.05).4.Analysis of Estated and SCAFS:At the level of the genus,enteric bacteria related to the concentration of the acetate include bloodthobacillus,genus of Tumorbacter,genus Predae,Gibrobacteria,and Tasarin_XIVB.Enterobacterians related to the concentration of acetate are genus and rods.Intestinal bacteria related to the concentration of propionate include Collins,genus of Food Valley,Food Gloree,Horbacteria,and Paracethur_xivb.Enterobacteris related to propionate concentrations include Cycotic,genus of Weisl,amino acid bacteria,and tumor gastrococococcterns.Intestinal bacteria related to the concentration of areotic acid include granulococcal bacteria,Vilular Salmonella,Horbais,and Bacteria_xivb,and Fusicartenibacter.Enterobacteris,which are negatively related to the concentration of isotinicate,are genus,amino acid bacteria,and Weisji.Conclusions1.The structure of the intestinal flora in the MS patient and the MS combined CHD group has undergone significantly changes,which is mainly manifested by the decrease in the average relative abundance of the beneficial bacteria compared with the control group,and the increase in the average relative abundance of the conditional flora group Essence.2.The concentration of serum,propionate,and benticate in the MS group increased significantly,and the concentration of serum isolate acid in the MS combined with the CHD group of patients with CHD group increased significantly.3.The changes of the intestinal flora structure and the SCFAS concentration in serum play an important role in promoting the occurrence of metabolic syndrome and further development into coronary heart disease.