Correlation Of 25-hydroxyvitamin D With Cognitive Impairment In Parkinson’s Disease

Research background:Parkinson’s disease(PD)is one of the most common neurodegenerative diseases among the middle-aged and elderly,and most patients develop cognitive impairment in the middle and late stages of the disease,which not only causes great suffering but also places a heavy burden on the family and society.However,the cause of cognitive impairment is not fully understood.It has been shown that Vit D is effective in inhibiting pro-inflammatory factors and protecting neuronal cells.Elevated serum Cys C levels may be strongly associated with the development of mild cognitive impairment.Brain-derived neurotrophic factor(BDNF)protects neuronal function and reduces neuroinflammatory damage,and IL-1β is a typical inflammatory cytokine that regulates a variety of physiological activities in the nervous system.In the body,Vit D is basically in the form of 25-hydroxyvitamin D(25(OH)D),which is widely distributed in glial and neuronal cells,and is effective in reducing toxic damage to dopaminergic neurons,thus better protecting the human nervous system.Purpose:Study of the correlation between serum 25(OH)D,Cys C,BDNF and IL-1βlevels and cognitive impairment in patients with Parkinson’s disease.Methods:In a case-control study,100 patients with Parkinson’s disease and 100 controls(without complaints of cognitive impairment)were selected according to the Mo CA scale.Socio-demographic data(e.g.age,gender,years of education,etc.)and general clinical information(past history,personal history,family history)were collected.25(OH)D,Cys C,BDNF,IL-1βlevels were measured before and after treatment using a fully automated biochemical analyser,respectively,The levels of 25(OH)D,Cys C,BDNF,IL-1β,Mo CA score and UPDRS score were measured before and after treatment using a fully automated biochemical analyser.Results:Cognitive function scores and serum 25-hydroxyvitamin D levels in the case group were lower than those in the control group(p < 0.05).UPDRS I,UPDRS II and UPDRS III scores were reduced in the case group after treatment,which was statistically different compared to the pre-treatment period(P < 0.05).Cys C and IL-1β decreased and BDNF increased after treatment,which was statistically different compared with pre-treatment(P < 0.05).Conclusion:Firetly,the degree of cognitive impairment in Parkinson’s disease is positively correlated with Mo CA,BDNF and 25-hydroxyvitamin D.Secoendly,IL-1β,Cys C,UPDRS and 25-hydroxyvitamin D levels are negatively correlated.