Risk Factors For Fibrosis Progression Of Connective Tissue Disease Associated Interstitial Lung Disease

Objective:Exploring the risk factors associated with the progression of interstitial lung fibrosis in patients with connective tissue disease-associated interstitial lung disease.Methods:Ninety patients with connective tissue disease-associated interstitial lung disease who came to our hospital from January 2020 to December 2022 were selected for the study,and the patients were grouped according to their progression of interstitial lung fibrosis as the group with progression of connective tissue disease-associated interstitial lung disease fibrosis(n=40)and the group with no progression of connective tissue disease-associated interstitial lung disease fibrosis(n=50).The basic clinical data of patients in both groups at baseline were collected,and the indicators associated with the progression of interstitial lung fibrosis in patients with connective tissue disease-associated interstitial lung disease were analyzed by independent sample t-test and χ2 test;the independent risk factors affecting the progression of interstitial lung fibrosis in patients with connective tissue disease-associated interstitial lung disease were analyzed by logistic regression;the measures with statistically significant differences were analyzed by Med Calc software The ROC curve analysis was performed to explore the predictive value of interstitial fibrosis progression in patients with connective tissue disease-associated interstitial lung disease.Results:1.90 patients with connective tissue disease-associated interstitial lung disease were 23 to 86 years old,with a mean age of(55.04±13.94)years;21 cases(23.33%)were male and 69 cases(76.67%)were female.2.The differences between the two groups in terms of age,gender,disease duration,hypertension,and diabetes mellitus were not statistically significant(P >0.05).3.The differences in leukocytes,platelets,hemoglobin,lymphocyte count,sedimentation,CRP,blood uric acid,albumin,Ig G,Ig A,Ig M,ferritin,and interleukin6 between the two groups were not statistically significant(P>0.05);the calcitoninogen levels of patients in the group with progressive connective tissue disease-associated interstitial lung disease were higher than those in the group without progressive connective tissue disease-associated interstitial lung disease The difference was statistically significant(P<0.05).4.The differences between the two groups were statistically significant(P<0.05)in cough,sputum,Raynaud’s phenomenon,chest tightness,shortness of breath,arthralgia,rash,FVC,DLCO,ground glass shadow,latticework,honeycomb,and patchy shadow;the differences between the two groups were not statistically significant(P>0.05)in gastroesophageal reflux,dry mouth,morning stiffness,emphysema,and pulmonary alveoli.5.Calcitoninogen,FVC,DLCO,ground glass shadow,and latticework were independent risk factors affecting the progression of pulmonary interstitial fibrosis in patients with connective tissue disease-associated interstitial lung disease.6.The AUCs of calcitoninogen,FVC,and DLCO were 0.637,0.721,and 0.760,respectively,with optimal cut-off values of 0.11,80.5,and 86,respectively.Conclusion:Calcitoninogen,FVC,DLCO,ground glass shadow,and latticework are risk factors affecting the progression of pulmonary interstitial fibrosis in patients with connective tissue disease-associated interstitial lung disease...