The Relationships Between OSAHS And Obesity And Specific Blood Pressure Levels And Blood Pressure Abnormalities

Object : To assess the relationship between obstructive sleep apnea hypoventilation syndrome(OSAHS)and obesity and blood pressure,and to further analyze whether there is an interaction between the effects of OSAHS and obesity on blood pressure.Methods: Retrospective analysis of adult patients who underwent polysomnography monitoring at the First Affiliated Hospital of Nanchang University from January 2014 to August 2022 were divided into four groups according to the presence or absence of severe OSAHS and obesity,and the relationship between moderate to severe OSAHS and obesity and blood pressure in men and women was analyzed separately.The main effects and interactions of severe OSAHS and obesity on systolic blood pressure(SBP)and diastolic blood pressure(DBP)were examined using ANCOVA;the relationship between severe OSAHS and obesity and blood pressure abnormalities(including hyper systolic blood pressure(hyper-SBP),hyper diastolic blood pressure(hyper-DBP)and hypertension)was clarified using logistic regression,and the interaction effects of severe OSAHS and obesity on blood pressure abnormalities were explored.Results: A total of 686 patients,including 589 males and 97 females,were included.In male patients,after adjusting for confounders such as age,blood glucose level,smoking and alcohol consumption,there was a significant main effect of obesity on SBP and DBP,and a significant main effect of severe OSAHS on DBP,but there was no interactions of obesity and severe OSAHS on SBP or DBP.Logistic regression results showed that after adjusting for multiple confounders,obesity was independently associated with hyper-SBP,severe OSAHS was independently associated with hyper-DBP and hypertension,and there was no significant interaction of severe OSAHS and obesity on blood pressure abnormalities.In female patients,after adjusting for multiple confounders,there was a significant main effect of obesity on DBP,while there was no significant main effect of severe OSAHS on either SBP or DBP,and there was no interaction of obesity and severe OSAHS on SBP or DBP.Logistic regression results showed that obesity was independently associated with hyper-SBP and hypertension,and severe OSAHS was independently associated with hyper-DBP.There was no significant interaction of severe OSAHS and obesity on blood pressure abnormalities.Conclusion: This study found that severe OSAHS and obesity were significantly independently associated with specific blood pressure levels and specific blood pressure abnormalities in males and in females.There was no interaction of severe OSAHS and obesity on blood pressure levels and blood pressure abnormalities either in males or in females.