Clinical Efficacy Of Non-invasive Ventilator In Patients With Chronic Obstructive Pulmonary Disease

Objective: Chronic obstructive pulmonary disease(COPD)is a respiratory disease.Non-invasive ventilator is one of the main methods of mechanical ventilation for COPDpatients.Thisstudyinvestigated theclinical efficacy of non-invasiveventilator in patients with COPD.Methods: Atotal of 123 patients with COPD companied with respiratory failure who were treated in our hospital from September 2020 to December 2021 were selected as theresearch objects.Among them,59 patients received conventional treatment served as the control group,and 64 patients received non-invasive ventilator assisted breathing therapy on the basis of conventional treatment served as the observation group.Records of clinical effects,lung function index(including forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),peak expiratory glow rate(PEFR))before andafter thetreatment,dyspnea(including Borgscoreandrespiratory problem score)before and after the treatment,blood gas index(including the arterial blood CO2 partial pressure(Pa CO2),arterial blood oxygen partial pressure(Pa O2),acidity(p H),blood oxygen saturation(Sp O2))before and after the treatment,inflammation markers(includingtumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8,C-reactive protein(CRP)and albumin(ALB))before and after the treatment,time of symptom resolution and length of hospital stay,life quality score and physiological indicators(including respiratory rate(RR)and heart rate(HR)before and after treatment).Results:Thetherapeuticeffectofobservationgroupwassignificantlybetterthanthat of control group.The FEV1,FVC and PEFR of the observation group before treatment were not significantly different from those of the control group,while the FEV1,FVC and PEFR of the observation group after treatment were significantly higher than those of the control group(p<0.05).The Borg score and respiratory problem score of the observation group before treatment were not significantly different from those of the control group,while the respiratory problem score of the observationgroupaftertreatmentweresignificantlylowerthanthoseofthecontrol group(p<0.05).Pa CO2,Pa O2,Sp O2 and p Hin the observation group before treatment were not significantly different from those in the control group,but Pa CO2 after treatment was significantly lower than that in the control group,and Pa O2,Sp O2 and p H were significantly higher than those in the control group(p<0.05).The disappearance timeofdyspnea,sputumandcoughsymptoms intheobservationgroup was significantly less than that in the control group,and the hospitalization time was significantly shorter than that in the control group.The life quality of patients in the observationgroupwashigherthanthatofthecontrolgroup.Thelevelsof TNF-α,IL-6,IL-8,CRP and ALB in the observation group before treatment were not significantly different from those of the control group,while the TNF-α,IL-6,IL-8,CRP and ALB of the observation group after treatment were significantly lower than those of the control group(p<0.05).Conclusion: COPD patients with non-invasive ventilator have better treatment effect,with significantly improved lung function,decreased dyspnea,significantly improved blood gas analysis indicators,faster symptoms disappearance,less inflammation,shorter hospitalization time and better life quality.