To Explore The Clinical Efficacy Of Supplementing Qi And Activating Blood Circulation Combined With Conventional Western Medicine In The Treatment Of Coronary Heart Disease Based On Meta-analysis

Objective:To evaluate the clinical efficacy of supplementing qi and activating blood combined with conventional western medicine in the treatment of coronary atherosclerotic heart disease by Meta-analysis.Methods: By searching CNKI,Wan Fang,VIP,Pubmed,Embase,Cochrane Libray and other databases,Randomized controlled trail(RCTS)about supplementing Qi and activating blood circulation combined with conventional western medicine for coronary heart disease were collected from the database establishment to October 31,2022.The basic characteristics,intervention measures,and outcome indicators of the research objects meeting the criteria were screened and included.Bias risk assessment was conducted for the included studies,and Meta-analysis of the study data was performed using Review Manager5.4 software.Results: A total of 3303 relevant literatures were retrieved.According to the inclusion criteria and exclusion criteria,a total of 21 literatures meeting the criteria were finally included,all of which were Chinese literatures.A total of 2539 patients were included,including 1287 in the treatment group and1252 in the control group.The results of Meta-analysis showed that:(1)In the curative effect of angina pectoris,supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was better than conventional western medicine alone,the difference was statistically significant,as follows: OR=3.46,95%CI(2.78,4.31),P < 0.01;(2)In the frequency of angina pectoris,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,the difference was statistically significant,as follows: SMD=-1.45,95%CI(-1.76,-1.13),P < 0.01;(3)In the duration of angina pectoris,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,and the difference was statistically significant,as follows: SMD=-1.32,95%CI(-1.76,-0.88),P < 0.01;(4)In terms of the efficacy of electrocardiogram,supplementing Qi and activating blood combined with conventional western medicine in the treatment of coronary heart disease was better than conventional Western medicine alone,the difference was statistically significant,as follows: OR=2.40,95%CI(2.01,2.87),P < 0.01;(5)In terms of serum total cholesterol level,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,and the difference was statistically significant,as follows: SMD=-0.64,95%CI(-0.85,-0.43),P < 0.01;(6)In terms of serum triglyceride level,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,the difference was statistically significant,as follows: SMD=-1.01,95%CI(-1.47,-0.55),P < 0.01;(7)In terms of serum low density lipoprotein cholesterol level,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,the difference was statistically significant,as follows: SMD=-1.15,95%CI(-1.54,-0.77),P < 0.01;(8)In terms of serum high density lipoprotein cholesterol level,the effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was better than that of conventional Western medicine alone,the difference was statistically significant,as follows: SMD=1.26,95%CI(0.45,2.07),P < 0.01;(9)In terms of serum C-reactive protein level,the improvement effect of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease was more significant than that of conventional western medicine alone,the difference was statistically significant,as follows: SMD=-1.68,95%CI(-2.60,-0.77),P < 0.01;(10)In terms of the efficacy of TCM symptoms,supplementing Qi and activating blood combined with conventional western medicine in the treatment of coronary heart disease was better than conventional Western medicine alone,and the difference was statistically significant as follows: OR=4.03,95%CI(2.14,7.58),P < 0.01;(11)In terms of adverse reactions and safety indexes,the adverse reactions OR safety performance of supplementing Qi and activating blood circulation combined with conventional western medicine in the treatment of coronary heart disease were basically similar to that of Western medicine alone,and the difference was not statistically significant,as follows: OR=0.66,95%CI(0.02,18.58),P >0.05.Conclusions:(1)In terms of angina pectoris and electrocardiogram,supplementing Qi and activating blood combined with conventional western medicine in the treatment of coronary heart disease was superior to western medicine alone in improving angina pectoris and electrocardiogram efficacy,reducing the frequency of angina attacks and shortening the duration of angina pectoris;(2)In the regulation of blood lipids,compared with the treatment of coronary heart disease with Western medicine alone,supplementing Qi and activating blood circulation combined with conventional Western medicine can effectively reduce the levels of serum total cholesterol,triglyceride and low density lipoprotein cholesterol,and improve the levels of high density lipoprotein cholesterol;(3)In terms of regulating the level of serum inflammatory factors,the effect of supplementing Qi and activating blood combined with conventional western medicine was better than that of Western medicine alone in reducing C-reactive protein;(4)In terms of the efficacy of TCM symptoms,supplementing Qi and activating blood combined with conventional western medicine had a more significant effect on improving TCM symptoms than the simple western medicine group;(5)In terms of adverse reactions and safety performance,the adverse events of supplementing Qi and activating blood circulation combined with conventional western medicine were similar to those of treating coronary heart disease with Western medicine alone,showing no obvious difference,which could not explain the increase or decrease of adverse events of supplementing qi and activating blood circulation under the condition of conventional Western medicine.