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Clinical Study On The Treatment Of Acute Gouty Arthritis Of Ankle Joint Damp-heat Accumulation Type With Addition And Subtraction Ermiao Powder And Xuanbi Decoction

Posted on:2024-05-27Degree:MasterType:Thesis
Country:ChinaCandidate:Y XiaoFull Text:PDF
GTID:2544306938954009Subject:Fractures of TCM science
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Objective: In this study,the clinical efficacy of the ancient classical formula Ermiao Powder combined with Xuanbi Decoction was compared with diclofenac sodium double-released enteric capsules for the treatment of acute gouty arthritis of the ankle joint.The clinical efficacy and significance of the treatment of acute gouty arthritis of the ankle joint with the combination of Ermiao Powder and Xuanbi Decoction were analyzed and evaluated,and new ideas for the treatment of acute gouty arthritis of the ankle joint and clinical basis and methods for the treatment of this disease were inspired.Methods: The study subjects were all patients with acute gouty arthritis of the ankle joint with damp-heat entrapment treated in the outpatient department of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,60 patients from 01/2022 to 01/2023.Age(18-70 years old).A total of 60 study subjects who met the inclusion criteria were randomly divided into two groups,30 cases in the treatment group and30 cases in the control group.All study subjects were given basic treatment such as diet and exercise.On this basis,the treatment group was given the Chinese medicine soup Ermiao Powder combined with Xuanbi Decoction plus reduction orally for 7 days;the control group was given diclofenac sodium double-release enteric capsules orally for 7 days,and the time of pain relief,pain VAS score,joint swelling score and the change of Chinese medicine symptoms score were recorded and compared between the two groups before and after the treatment.(WBC),C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR).The data collected were statistically analyzed using SPSS 27.0 software.Results:1.60 observation subjects who met the inclusion criteria,of which 4 cases were detached and 56 cases completed observation and treatment.There was no significant difference between the two groups of observation subjects in this study in terms of basic information gender,age,disease location,and disease duration,P > 0.05.2.There was no significant difference in the pain VAS score,joint swelling score,Chinese medicine evidence score and laboratory index between the two groups of study subjects before treatment,P>0.05.3.Within-group comparison of pain VAS scores,joint swelling scores,TCM symptoms scores and WBC,CRP and ESR before and after treatment between the two groups,P < 0.05,with statistically significant differences.4.Intra-group comparison of pain VAS scores,joint swelling scores,TCM symptom scores and WBC,CRP and ESR of the study subjects in both groups after treatment: P < 0.05,with statistically significant differences.5.Comparison of the time to start pain relief between the two study groups showed a statistically significant difference at P < 0.01.And the time to start pain relief in the treatment group was longer than that in the control group.6.The comparison of blood uric acid index between the two groups before treatment and the comparison of intra-group and inter-group after treatment showed that P > 0.05,and the difference was not statistically significant.7.Comparing the pain efficacy and Chinese medical evidence efficacy of the two study subjects before and after treatment,the differences were statistically significant with P < 0.05 by rank sum test.Conclusion(s): 1.Ermiao Powder combined with Xuanbi Decoction plus reduction is more effective than diclofenac sodium double-release enteric capsule in reducing patients’ TCM symptoms,pain VAS scores,joint swelling scores,reducing patients’ blood leukocyte index,C-reactive protein index and blood sedimentation index.This formula is safe and reliable for the treatment of acute gouty arthritis of the ankle joint caused by damp-heat accumulation.2.Ermiao Powder combined with Xuanbi Decoction Plus Decrease is better than Diclofenac Sodium Double Release Enteric Capsules in pain relief,but Diclofenac Sodium Double Release Enteric Capsules is better than Ermiao Powder combined with Xuanbi Decoction Plus Decrease in pain relief time.3.Neither Ermiao Powder combined with Xuanbi Decoction Plus Decrease nor diclofenac sodium double-release enteric capsules had the efficacy of lowering blood uric acid.4.No serious adverse events occurred in both study groups during treatment,and both treatment regimens were low risk.
Keywords/Search Tags:Ermiao Powder combined with Xuanbi Decoction, ankle joint, Gouty arthritis, diclofenac sodium, damp-heat accumulation
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