Common Patterns And Chinese Medicinal Combination Rules For Flaccidity Of Bones Basing On "Chinese Medical Classics":A Data-mining Study

Objective : By combining literature search and statistical analysis,this paper based on ancient literature to comb the development source of flaccidity of bones,explore the theoretical understanding of traditional Chinese medicine(TCM)on the treatment of that,then systematically sort out the prescriptions and Chinese herbs for treating the flaccidity of bones.Finally,summarizing the principle-method-formula-medicine of the treatment of flaccidity of bones,to further guide and improve the clinical curative effect of flaccidity of bones.The ultimate goal is to provide new ideas for the theoretical and practical work of The ultimate goal is to provide new ideas for the theoretical and practical work of bone atrophy and its related diseases in modern medicine and its related diseases medicine.Methods : In the "Chinese Medical Classics",according to the search terms "Guwei",to retrieve and screen out the relevant clause,and summarize the development origins,definition contents,pathogenesis.Effective prescriptions for the treatment of flaccidity of bones in past dynasties are counted to establish a database with formula titles and compositions to carry on frequency analysis,four natures and five flavors analysis,cluster analysis,and regression analysis.Combined with the theory of traditional Chinese medicine,the statistical results were analyzed.Results : 1.There are discussions on flaccidity of bones in ancient books,involving bone impediment,bone withered,bone exhaustion,deficiency and other categories.Most of them related to osteoporosis,sarcopenia,but each has its own characteristics.For instance,during the Warring States to Han Dynasty period,it is put that gastroenteroneurosis and wind-strike acute arthritis are related to flaccidity of bones.This opinion showed that in addition to osteoporosis,flaccidity of bones was also related to arthritis and its resulting dysfunction.The flaccidity of bones discussed in the Ming and Qing Dynasties is not only related to the manifestations of limb weakness and inability to exercise after heat stroke,but also conforms to the disease category of bone tuberculosis.2.The pathogenesis characteristics of flaccidity of bones include spleen and kidney deficiency,lung heat consuming body fluid,wetness-heat evil of Yangming,liver and kidney deficiency,deficiency and stasis mix.Therapy with syndrome differentiation includes invigorating spleen and nourishing kidney,clearing lung combined invigorating yin,clearing heat and drain dampness,reinforcing liver benefiting kidney,restoring vital energy and activating blood flow.3.By searching the "Chinese Medical Classics",111 prescriptions for the treatment of bone fistula were screened out,there were 183 Chinese herbs.After analyzing them,(1)the top five high-frequency Chinese herbs were ox-knee,prepared rehmannia root,Indian Bread,Chinese Angelica,ginseng;the kidney meridian is the main meridian,followed by the liver,spleen,heart,lung,and stomach meridians;the most medicinal ingredients is sweetish taste,secondly is pungent and bitterness.(2)Through high-frequency cluster analysis of traditional Chinese herbs,six clustering prescriptions can be formed,namely:(1)common yam rhizome,Asiatic cornelian cherry fruit,prepared rehmannia root.(2)ox-knee,eucommia,saline cistanche,Chinese dodder seed,indianmulberry.(3)fructus schizandrae,milkvetch root.(4)mankshood,noble dendrobium stem herb,cassia bark,tuckahoe,ginseng.(5)Chinese angelica,liquorice root.(6)amur corktree bark,largehead atractylodes rhizome.(3)Through the analysis of high-frequency TCM association rules,274 pairs of drug combinations with high correlation degree were obtained.Among them,3 groups of association Chinese herbs combinations with confidence value of 100 % and support value exceeds 10 % were prepared rehmannia root,noble dendrobium stem herb,and ginseng,prepared rehmannia root,saline cistanche,and ginseng,prepared rehmannia root,Chinese dodder seed,and tuckahoe.Conclusions: 1.In traditional Chinese medicine,flaccidity of bones and bone rheumatism,bone withered,bone exhaustion and consumptive disease are both interrelated and independent.Flaccidity of bones is closely related to osteoporosis and sarcopenia in modern medical diseases.And it is similar with arthritis,rhachitis/osteomalacia bone tuberculosis.So the treatment of flaccidity of bones should first clear clinical diagnosis.2.Flaccidity of bones is mostly based on deficiency of viscera and blood.In the meantime,its superficialities are ecchymosis,dampness and heat.The treatment of flaccidity of bones should be based benefiting onliver-spleen-kidney,take heat and drain dampness and activating blood flow into accountclearing.3.The most commonly used herbs for the treatment of flaccidity of bones in ancient physicians are ox-knee,prepared rehmannia root,Indian Bread,Chinese Angelica,ginseng.These herbs are benefit functional,and the main meridian of them is the kidney meridian,most drug propertythe is warm,most medicine flavour is sweet.In clinical practice,we can use the obtained clustering prescriptions and high-frequency TCM association rules to treat flaccidity of bones such as osteoporosis and sarcopenia through appropriate drug addition and subtraction.