Correlation Study Of TCM Constitution And TCM Syndrome Distribution In Postmenopausal Pre-clinical Alzheimer’s Disease Patients

Objective: To explore the distribution of Traditional Chinese Medicine(TCM)constitution and TCM syndrome elements of postmenopausal preclinical Alzheimer’s disease(AD)patients,further analyze the correlation.From the perspective of TCM constitution and the tendency of AD preclinical,to provide the direction and basis for clinical early diagnosis and regulation of TCM constitution and treatment of AD.Methods: 155 cases of preclinical AD patients and 66 cases of with Normal Control Group(NC)in the same age were collected to compare the distribution of TCM constitution and TCM syndrome elements.Then the logistic regression Forward Stepwise(Likelihood Ratio)regression was used to analyze the correlation between TCM constitution and TCM syndrome elements distribution in preclinical patients with postmenopausal AD.Results: 1.General data: A total of 221 subjects were included in this study,including 155 in postmenopausal AD group and 66 in NC group.There was no significant difference in the composition ratio of age,education level,age at menopause and pregnancy frequency(P> 0.05).2.The MMSE and Mo CA scale scores were higher in NC group than in AD preclinical group,the difference was statistically significant(P<0.01).3.There were significant differences in the composition ratios of moderate and biased constitutions between the two groups(P<0.01).There were significant differences in the composition ratios of the nine constitutions between the two groups(P<0.01).Among them,postmenopausal AD preclinical patients physique distribution: mainly partial constitution,accounting for 66.5%.Among the partial constitutions,Yang deficiency constitution(20.0%),blood stasis constitution(15.5%),and Qi deficiency constitution(11.6%)are the main ones,followed by Qi stagnation constitution(7.8%),Yin deficiency constitution(6.5%),Phlegm-dampness constitution(1.9%),Special endowment constitution(1.9%),and Damp-heat constitution(1.3%).4.There were significant differences in the frequency composition ratio of disease location and disease nature syndrome elements between the two groups(P<0.05).The distribution of syndrome elements in postmenopausal AD preclinical patients is as follows:(1)There are 5 syndrome elements involved in the disease location,among which Liver,Kidney,Mind(brain)are the main ones,followed by Spleen and Heart.(2)A total of 9 syndrome elements are involved,among which Blood deficiency,Qi deficiency,Qi stagnation,Yin deficiency and Yang deficiency are the main ones,followed by Yang hyperactivity,Essence deficiency,Phlegm and Blood stasis.(3)The deficiency syndrome elements mainly includes Blood deficiency(23.3%),Qi deficiency(18.2%),Yin deficiency(14.4%)and Yang deficiency(10.6%);the excess syndrome elements mainly has Qi stagnation(17.3%)and Yang hyperactivity(7.4%).(4)There was a significant difference between the two groups in terms of liver and kidney evidence scores(P<0.05).5.Postmenopausal AD preclinical patients: the distribution of syndrome element integral distribution of liver,kidney,and mind(brain)in common constitution is different(P<0.05);There are differences in the distribution of blood deficiency and Qi deficiency syndrome elements in different physiques(P<0.05).6.Logistic regression correlation analysis of constitution and syndrome elements:compared with NC group,(1)postmenopausal AD preclinical patients:there is a positive correlation between Qi deficiency constitution and disease location syndrome Kidney(P<0.05);There is a positive correlation between Yin deficiency constitution and disease location syndrome elements of Kidney,Spleen and Liver(P<0.05);There is a positive correlation between Qi stagnation constitution and Liver,Heart and Mind(brain)of disease location syndrome elements(P<0.05);There is a negative correlation between moderate constitution and disease location syndrome element Spleen(P<0.05).(2)There is a positive correlation between Qi deficiency constitution and Blood deficiency and Essence deficiency(P<0.05);There is a positive correlation between Qi stagnation constitution and Qi stagnation(P<0.05).Conclusion(s):1.The distribution of TCM constitution in postmenopausal AD preclinical patients is mainly partial constitution.And Yang deficiency constitution,Blood stasis constitution,Qi deficiency constitution for its susceptible constitution.2.Postmenopausal AD preclinical patients with disease location syndrome elements are mainly Liver,Kidney,Mind(brain),while involving the Spleen,Heart.The overall disease syndrome elements are: Blood deficiency,Qi deficiency,Qi stagnation,Yin deficiency,Yang deficiency,Yang hyperactivity,Essence deficiency,Phlegm,Blood stasis.The main syndrome elements of deficiency are: Blood deficiency,Qi deficiency,Yin deficiency and Yang deficiency.The main excess syndrome elements are qi stagnation and yang hyperactivity.3.For postmenopausal women with preclinical AD:(1)Patients with qi deficiency constitution are more likely to have syndrome of kidney,Yin deficiency constitution is more likely to have syndrome of kidney,spleen and liver,and those with Qi depression constitution are more likely to have syndrome of Liver and Mind(brain).And moderate constitution patients are not easy to show the syndrome of the Spleen.(2)Patients with Qi deficiency constitution are more likely to have pathological Blood deficiency and Sperm deficiency,and patients with Qi depression are more likely to have syndrome performance of pathological Qi stagnation.