Clinical Observation Of Jianpi Bushen Decoction In The Treatment Of Fatigue In Myelodysplastic Syndrome

Objective This study aimed to observe the efficacy of Jianpi Bushen Decoction(JBD)on fatigue and peripheral blood indicators in patients with myelodysplastic syndrome and to analyze the clinical significance of JBD in the treatment of myelodysplastic syndrome.Methods In this study,30 patients with myelodysplastic syndrome were randomly divided into experimental group and control group,with 15 cases in each group.The control group was treated with conventional western medicine such as blood transfusion,blood promotion or demethylation,and the experimental group added JBD on the basis of the control group.After 8 weeks of treatment,the Piper fatigue scale(PFS)was used to evaluate the scores before and after treatment in both groups,and peripheral blood counts,cytokines,and biochemical indicators were analyzed.Results 1.PFS: the cognitive dimension score of the control group after treatment was lower(P<0.05),and the overall score,behavioral dimension,emotional dimension and perception dimension were not significantly improved compared with the pre-treatment dimension(P>0.05).Compared with the pre-treatment period,the overall score,behavioral dimension,affective dimension,perceptual dimension and cognitive dimension decreased in the experimental group(P<0.05),the improvement was more in the emotional and cognitive dimensions.2.Evaluation of the efficacy of TCM symptoms: After treatment,there was no improvement in the four symptoms of reduced diet,edema,weakness in the waist and knees and cold extremities in the control group(P>0.05),and the experimental group had significant improvement in diet and weakness in the waist and knees 3.Peripheral complete blood count: the three-line platelets in the control group were not significantly improved compared with before treatment,the neutrophils,red blood cells and hemoglobin in the experimental group were significantly increased(P<0.05),and white blood cells also increased to a certain extent,but the gap was not statistically significant(P>0.05)。4.Cytokine levels: there were no noticeable changes in IL-2,IL-4,TNF-α,IL-10,IL-6,IL-8,IL-17 A,IL-γ,IL-α,IL-5,IL-12p70,IL-1β after treatment in the control group,in the other hands,IL-4,IL-5 and IL-17 A were significantly elevated within the normal range(P <0.05)。 5.Biochemical indexes:There were no changes in serum total protein,albumin and globulin levels after treatment in the two groups,and sodium and serum iron levels did not improve significantly,too.Serum potassium levels increased and lactate dehydrogenase levels decreased in the experimental group after treatment,while no significant changes were seen in the control group.Conclusion JBD combined with conventional treatment of western medicine can improve the feel of fatigue and TCM syndrome,improve the quality of life and improve the prognosis,and increase some blood cell counts,regulating cytokine content,improve serum potassium level and reduce lactate dehydrogenase.