| Objective: This study is to explore the clinical efficacy of modified Mahuang Fuzi Asarum Decoction combined with ginger separated moxibustion in the treatment of perennial allergic rhinitis(lung qi deficiency cold syndrome)through a clinical randomized controlled experiment,and compare its efficacy with that of the control group of montelukast sodium tablets combined with fluticasone propionate nasal spray,to clarify the exact efficacy and advantages of the combination of internal and external treatment of traditional Chinese medicine in the treatment of allergic rhinitis.Methods:From October 2021 to October 2022,60 patients who were diagnosed as perennial allergic rhinitis(lung-qi deficiency cold type),who met the inclusion criteria and volunteered to participate in this study,were selected from the otorhinolaryngology clinic of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine(Shandong Provincial Hospital of Traditional Chinese Medicine).Sixty patients were randomly divided into the treatment group(oral modified Mahuang Fuzi Asarum Decoction combined with ginger moxibustion),30 cases,and the control group(oral montelukast sodium tablets combined with fluticasone propionate nasal spray),30 cases.The treatment group was given oral Chinese medicine decoction,one dose per day,and ginger moxibustion treatment,once every 4 days.The control group was given montelukast sodium tablet orally,10mg/time,once a day,plus fluticasone propionate nasal spray,2 sprays/nostril,once a day in the morning.The treatment time of both groups was 28 days,and the drug was stopped for 3 months after the treatment for follow-up.Before and after the treatment and during the follow-up,the visual analogue scale(VAS),the integral table of traditional Chinese medicine symptoms,and the quality of life questionnaire of nasal conjunctivitis(RQLQ)were used for evaluation and analysis,and adverse reactions were recorded.The data of the two groups of patients were sorted and analyzed using Excel and SPSS26.0 statistical software.Results:The baseline data(gender,age,pre-treatment VAS score,syndrome score,quality of life score)of the two groups of patients before treatment were tested respectively,and P>0.05 was obtained.The data of the two groups were not statistically different and were comparable.During the treatment cycle and follow-up period,there were no cases of rejection and shedding in both groups.1.After treatment: the total effective rate of the treatment group was93.33%,and the total effective rate of the control group was 83.33%.After test,there was significant statistical difference between the two groups(P<0.01),and the advantage of the treatment group was more obvious.The VAS score,TCM syndrome score,and RQLQ score of the two groups were compared within the group.The test showed that the VAS score,total syndrome score,total RQLQ score,and individual score of each group were significantly lower than those before treatment(all P<0.01).Then the comparison between groups showed that there was no difference in the score of nasal congestion between the two groups(P>0.05).The score of sneeze,nasal itching and secondary symptoms in the treatment group were lower than those in the control group(all P<0.05),and the score of other symptoms were significantly lower than those in the control group(all P<0.01);In terms of quality of life,the nasal symptom score of the treatment group was significantly lower than that of the control group(P<0.01),and the activity score,non-nasal eye symptom score and total RQLQ score were lower than those of the control group(both P<0.05).There was no difference between the two groups in sleep score,actual problem score,eye symptom score and emotional score(both P>0.05).2.Follow-up: the total effective rate of the treatment group was 83.33%,and the total effective rate of the control group was 66.67%.The advantage of the treatment group was more significant(P<0.01).The VAS score,TCM syndrome score,and RQLQ score of the two groups were compared within the group.The test showed that the VAS score,total syndrome score,total RQLQ score,and individual score of each group were significantly lower than those before treatment(all P<0.01).Then,there was no difference in the score of nasal congestion and nasal itching between the two groups(P>0.05).The score of sneeze in the treatment group was significantly lower than that in the control group(P<0.05),and the score of other syndromes were significantly lower than that in the control group(P<0.01);In terms of quality of life,the score of nose symptoms in the treatment group was significantly lower than that in the control group(P<0.01).The score of actual problem score,emotional score and total score of RQLQ were lower than those in the control group(P<0.05).There was no difference in activity score,sleep score,non-nasal eye symptom score and eye symptom score(all P>0.05).Conclusion:Modified Mahuang Fuzi Asarum Decoction combined with ginger moxibustion has a good clinical effect in treating perennial allergic rhinitis(lung-qi deficiency cold syndrome).Modified Mahuang Fuzi Asarum Decoction is based on the principle of warming the lung and dispersing the cold,supplementing qi and consolidating the exterior.It can also take into account the spleen and kidney,effectively balance the viscera function,and improve the patient’s physique;Ginger-separated moxibustion can achieve the function of warming yang and dispersing cold from the outside to the inside.The combination of the two treatments reflects the overall concept of traditional Chinese medicine and the advantages of internal and external treatment.This study shows that the short-term and long-term efficacy of the combination of internal and external treatment of traditional Chinese medicine is better than that of the combination of montelukast sodium tablet and fluticasone propionate nasal spray,and it is safe,and it is an effective means to treat allergic rhinitis of lung qi deficiency and cold type. |
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