| Objective:Through clinical observation,to compare the clinical efficacy of Silibin capsule alone and Pinxia Coix Seed decoction in the treatment of non-alcoholic fatty liver with phlegm-dampness internal resistance.At the same time,attention was paid to its safety,and the TCM syndrome,liver function,blood lipid,abdominal color ultrasound,liver instantaneous elastic imaging to determine the ratio of liver to kidney,body mass index and other indicators of Banxia Coix Decoction in patients with phlegm-dampness internal resistance non-alcoholic fatty liver were observed.To accumulate clinical data to improve the symptoms and prognosis of patients with phlegm-dampness internal obstruction nonalcoholic fatty liver disease,so as to seek safer and more effective treatment.Methods:Randomized controlled study was used,and 60 patients were numbered according to the time of visit,and randomly divided into observation group and control group,with 30 cases in each group.The control group was given silybin capsules.Observation group was also given the empirical formula of Zhao Xueyin,a famous old TCM in Shandong Province,Banxia and Coix Seed Decoction.The course of treatment was 12 weeks.Before and after treatment,TCM syndrome,liver function,blood lipid,abdominal color ultrasound,liver instantaneous elastic imaging and other indicators of liver and kidney ratio were observed,as well as related safety indicators,and statistical analysis was conducted.Results:1.For TCM syndrome,the overall effectiveness of TCM was 90% in the observation group and 80% in the control group,with a statistical difference(P<0.05);For syndromes,there was no significant difference in syndromes in the first two treatment groups(P>0.05).After treatment,the observed group was better than the control group(P<0.05).2.For liver function,the comparison between the two groups before trea tment showed no significant difference(P>0.05)in the four hepatic work endpoints in the two groups.There was a statistically significant differe nce between the indicators of hepatic work in both groups post-treatment and pre-treatment(P< 0.05).However,there was no statistical difference(P>0.05)between the ast indicators compared between the two groups after treatment,indicating higher efficacy in the observed group than in the c ontrol group.3.As for blood lipids,the comparison between the two groups before treatment showed no significant difference in blood lipids results(P>0.05).Improvement in all four indicators was better in both groups after treatment than before treatment(P<0.05).Furthermore,the observed group was better than the control group after treatment(P<0.01),indicating that the efficacy of the observed group was higher than that of the control group.4.For body mass index,there was no significant difference between the two groups(P>0.05)when comparing the two groups before treatment;In the intra-group post-treatment comparison,the body mass index decreased in both groups compared to pre-treatment(P<0.05);Comparison between the groups after treatment showed that the observed group had a better reduction in body mass index than the control group(P<0.05),indicating that the efficacy of the observed group was higher than that of the control group.5.With respect to overindexing of liver color,there was no significant difference between groups before treatment(P>0.05);Colour overindexing decreased in both groups after treatment(P<0.05)and comparison between the Results:observation groups was better than that of the control group(P<0.05),indicating higher efficacy in the observation group than in the control group.6.In determining the liver/kidney ratio by instantaneous liver elastog raphy,no significant differences were observed between groups prior to tr eatment(P>0.05);The liver/kidney ratio decreased in both groups after tr eatment(P<0.05).And the post-treatment group was significantly better th an the control group(P<0.01).7.In terms of clinical safety,the associated pre-and post-treatment safety indicators were normal in both groups.No significant adverse effects or toxic effects were observed in both groups during the treatment period.Conclusion:Banxia Coix Seed Decoction in the treatment of phlegm-dampness internal obstruction type of non-alcoholic fatty liver can significantly improve the clinical syndroms of traditional Chinese medicine,liver function,blood lipid,abdominal color ultrasound,liver instantaneous elastic imaging to determine the ratio of liver to kidney and other indicators,and has a good clinical effect. |
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