| Purpose: Based on the theory of "endogenous heat toxin",to pay attention to the influence of micro inflammatory state in the process of diabetes kidney disease,to observe the clinical therapeutic effect of Xiehuo Jiedu Yangyin Recipe on diabetes kidney disease patients,and to explore the effectiveness and safety of the Chinese medicine treatment plan for diabetes kidney disease micro inflammation guided by the theory of "endogenous heat toxin",in order to furnish clinical foundation of Chinese medicine treatment of diabetes kidney disease.Methods: 66 clinical cases of micro deepening of diabetes with kidney disease(G1-3a A2 stage)of "heat toxin injuring yin type" meeting the inclusion criteria were randomly disconnected into the test group and the control group,with 33 cases in each group.The control group was administered with conventional treatment of western medicine,and the test group was treated with traditional Chinese medicine for purging fire,detoxicating and nourishing yin on the basis of western medicine.The observation course of both groups was 8 weeks.Observe the laboratory indexes such as hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),24-hour urine protein quantification(24h UTP),serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(e GFR),blood red albumin(Hb),serum albumin(ALB) before and after treatment in the two groups,record the TCM syndrome score and clinical efficacy changes before and after treatment,and conduct statistical analysis to objectively evaluate its effectiveness and safety.Results:(1)The control group completed 30 cases,while the experimental group completed 30 cases.Before treatment,there was no significant distinction between the two groups in terms of basic situations,laboratory indicators,and TCM disease score(P>0.05).(2)The indexes of 24 h UTP,hs-CRP and PCT in the two groups were improved after treatment(P<0.05).Although ALB increased among both groups after treatment,the difference was not statistically significant(P>0.05).(3)Following surgery,both groups’ clinical signs improved,and the TCM syndrome score decreased.The effective rate of TCM syndrome effect in the test group was 83.33%;The efficient frontier of TCM syndrome effect in the control group was 56.67%,and the variance among the two groups was statistically significant(P<0.05).(4)All these groups of patients’ clinical effectiveness improved before and after treatment.The control group’s total efficient frontier was 60%,while the test group’s complete effective rate was 86.7%.The difference between the two groups was statistically significant(P<0.05).(5)In both groups,there wereno obvious abnormalities in blood,urine,stool routine,electrocardiogram,or liver function before and after treatment.On the second day of treatment,2 patients in the control group had sicchasia and untoward reaction,the incidence of undesirable frequency was 6.67%,but the adverse reactions were mild,without special treatment,and the symptoms were relieved by themselves.At the beginning of treatment,one patient in the test group had mild diarrhea adverse reactions on the first day of taking the drug,with the incidence of adverse reactions of 3.33%.Because the adverse reactions were mild,the symptoms were relieved without exceptional remedy,and no adverse reactions occurred in the follow-up treatment,indicating that the safety of the test group was better than that of the control group.Conclusion: In the treatment of diabetic patients with kidney disease,the clinical symptoms were improved,the level of inflammatory factors was reduced,and the micro-inflammatory state was relieved.The overall remission degree of the disease was obviously better than that of the untreated group.Therefore,the prescription of reducing fire and detoxifying Yin can protect renal function by inhibiting the microinflammatory state of patients,thus delaying the progression of DKD.The theory of endogenous heat toxicity is effective and safe in the clinical treatment of diabetic kidney disease. |
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