Study Of TCM Constitution Distribution Characteristics And Related Factors In Patients With Amnestic Mild Cognitive Impairment

Objective:This study took patients with amnesian Mild Cognitive Impairment(aMCI)as the research object,analyzed the distribution characteristics of traditional Chinese medicine constitution in patients with aMCI,analyzed the relationship between major traditional Chinese medicine constitution and its related factors,and searched for risk factors.It provides a certain reference for the early clinical syndrome differentiation and physical regulation of aMCI patients from the perspective of traditional Chinese medicine constitution,and provides objective evidence for the early prevention and treatment of such diseases and the prevention of Alzheimer disease AD.Method:A total of 215 aMCI patients admitted to Weifang Hospital of Traditional Chinese Medicine(including outpatient department and ward)were collected for clinical cognitive function assessment through auditory word learning test(AVLT-H),Montreal Cognitive Scale(Mo CA),Simple Mental State Scale(MMSE)and other cognitive function related assessment scales.The patients were included in the daily living Ability Scale(ADL)and Clinical Dementia Scale(CDR).Information was collected for all cases meeting the inclusion criteria,including age,gender,BMI,past history and relevant laboratory indicators,etc.The physical type of patients was determined according to the physical evaluation table compiled by Professor Wang Qi.SPSS25.0statistical software was used for statistical analysis of the collected data,all measurement data were normal test,counting data were chi-square test.When the measurement data conform to normal distribution or homogeneity of variance,t test is used;otherwise,rank sum test is used.Logistic regression analysis was used to analyze the correlation factors,and the difference was statistically significant when P < 0.05.Result:(1)The proportion of biased constitution types in 215 aMCI patients from high to low was Qi deficiency(22.3%),phlegm-dampness(20.0%),blood stasis(16.3%),Yang deficiency(14.9%).(2)Through the correlation analysis of four kinds of biased constitution and various factors in aMCI patients,the results showed that qi deficiency quality was correlated with age,history of hypertension,lack of exercise,phlegm-dampness quality was correlated with abnormal TG,MBI,diabetes,heavy meat diet,blood stasis quality was correlated with abnormal Hcy and smoking history,Yang deficiency quality was correlated with BMI and drinking history.(3)Logistic regression analysis was carried out on the above four types of biased constitution and corresponding related factors in aMCI patients.The results showed that Qi-deficiency was positively correlated with age and history of hypertension,phlegm-dampness was positively correlated with abnormal TG,BMI and history of diabetes,blood stasis was positively correlated with abnormal blood Hcy,and Yang deficiency was positively correlated with BMI.Conclusion:(1)The proportion of biased constitution types in 215 aMCI patients from high to low was Qi deficiency,phlegm-dampness,blood stasis,Yang deficiency.(2)Age and history of hypertension were risk factors for aMCI patients with qi-deficiency.Abnormal TG,diabetes history and BMI were risk factors for aMCI patients with phlegm and dampness.Abnormal blood Hcy was a risk factor for aMCI patients with blood stasis.BMI is a risk factor for aMCI patients with phlegm-dampness and Yang deficiency.