The Analysis Of Influential Factors In Amnestic Mild Cognitive Impairment

Background:Mild cognitive impairment is an intermediate state between normal aging and dementia in the elderly, because of its high conversion to Alzheimer’s Disease,receiving so much concern.Amnestic mild cognitive impairment(a MCI),taking episodic memory barriers as its prominent manifestations, convert to AD with 10 times higher probability than the general population.So,a MCI is gradually becoming the focus of researcher’s attention, so finding the common risk factors between a MCI and AD can help us begin early diagnosis and interventions to AD.Objective:The main purpose of this study was investigating the levers of serum uric、lipid、glucose and plasma homocysteine in a MCI and AD groups.Methods:Using the case control study,according to MMSE score demarcation,the aMCI group were consisted of 40 patients, the severe AD group were consited of 13 patients, and the NC group were consited of 50 people with no cognitive impairment;and collecting social demographic information(such as age、gender、education level)and general clinical data(past medical history、personal history and family history);then using the automatic biochemical analyzer,the levels of serum uric acid(UA),total cholesterol(TC),triglyceride(TG), low density lipoprotein-cholesterol(LDL-C)high density lipoprotein-cholesterol(HDL-C),fasting plasma glucose(FPG)and homocysteine were detected in these groups.Result:From the outcome we could find,compared in aMCI 、severe AD and healthy controls groups,firstly,the UA levels were on average 254.34±54.21umol/l、214.28±30.96umol/l、334.79±51.42 umol/l,and the differences in this three groups had statical significance(P<0.05);secondly,TC levels were on average 4.93±0.35mmol/l、5.15±0.28mmol/l、4.60±0.55mmol/l,and the differences in this threegroups also had statical significance(P<0.05);thirdly,the LDL-C levels were on average2.48±0.38mmol/l、2.76±0.45mmol/l、2.46±0.33mmol/l,the difference between sever AD and healthy control groups had statical significance(P<0.05),but not between a MCI and healthy control groups;fourthly,the Hcy levels were on average:12.24±2.72umol/l、15.51±4.67umol/l、10.42±2.44umol/l,and the differences in this three groups had statical significance(P<0.05);Besides,the FPG level in this three groups had no statistical significance differences. Logistic regression analysis showed that UA is the protective factor to a MCI,while TC、Hcy were the risk factors.Conclusion:Above all,the conclusions are that,firstly,Uric acid has negative correlation with a MCI,and UA may be the protective factor to a MCI,we can find the low level UA in a MCI,and as the deterioration of the cognitive impairment,the level of UA will be lower. Secondly,Total cholesterol has positive correlation with a MCI,and may be a risk factor for a MCI.Thirdly,homocysteine also has positive correlation with a MCI,and may be a risk factor for a MCI.