Study On The Distribution And Correlation Of TCM Syndromes And Performance Under Enteroscopy Of Active Ulcerative Colitis

Objective: To investigate the distribution and correlation of TCM syndromes and performance under enteroscopy of AUC patients.To provide clinical basis for the prevention and treatment of this disease by combining disease differentiation and syndrome differentiation.Methods: This study included eligible AUC patients.Collect the clinical data of patients by using questionnaire and figure out TCM syndromes.Analyze the collected clinical data by using statistical software and investigate the distribution and correlation of TCM syndromes and performance under enteroscopy.Results: 1.Gengral information distribution:(1)This study included 188 patients.The ratio of male to female was 1.61:1.The minimum age of all patients is 20 years,the maximum age is 76 years,and the average age is 45.54 years old.There was no correlation between gender and age.(2)The patients with a course of disease of 1-5 years accounted for the largest proportion(48.40%),followed by patients with a course of disease of more than 10 years(23.94%),patients with a course of disease of 6-10 years(19.15%)and patients with a course of disease of less than 1 year(8.51%).2.Distribution and correlation of TCM syndromes:(1)Distribution of TCM syndromes: Liver depression and spleen deficiency syndrome accounted for the largest proportion(23.94%),followed by spleen deficiency and dampness syndrome(22.34%),large intestine damp-heat syndrome(21.81%),spleen and kidney Yang deficiency syndrome(18.62%),excessive heat toxin syndrome(6.38%),cold-heat complex syndrome(5.85%)and Yin blood deficiency syndrome(1.06%).(2)There was significant correlation between TCM syndromes and age.Large intestine damp-heat syndrome accounted for the most in young patients(33.70%).Spleen deficiency and dampness syndrome accounted for the most in middle-aged patients(32.20%).Spleen and kidney Yang deficiency syndrome accounted for the most in elderly patients(37.84%).(3)There was significant correlation between TCM syndromes and the course of disease.Large intestine damp-heat syndrome accounted for the most in patients with a course of disease of less than 1 year(50.00%).Liver depression and spleen deficiency syndrome accounted for the most in patients with a course of disease of 1-5 years(30.77%).Spleen deficiency and dampness syndrome accounted for the most in patients with a course of disease of 6-10years(38.89%).Spleen and kidney Yang deficiency syndrome accounted for the most in patients with a course of disease of more than 10 years(53.33%).(4)There was correlation between TCM syndromes and illness severity.Liver depression and spleen deficiency syndrome accounted for the most in mild patients(35.00%).Liver depression and spleen deficiency syndrome accounted for the most in moderate patients(32.43%).Large intestine damp-heat syndrome,spleen deficiency and dampness syndrome,spleen and kidney Yang deficiency syndrome accounted for the most in severe patients(22.52%).3.Distribution of performance under enteroscopy: Light red was the most common color of mucous membrane(44.68%).Congestion,edema,with rough mucosa or blurred vascular texture was the most common mucosa damage(57.98%).White moss was the most common attachment on the lesion surface(40.96%).The most common bleeding condition was no bleeding after contact(73.94%).The mucosa of terminal ileum was mostly smooth(89.89%).The most common shape of the intestinal cavity was shallower colon pocket and fuzzy fold shape(64.89%).E3(total colon)accounted for the largest proportion of range of lesion(45.74%).4.Correlation between TCM syndromes and performance under enteroscopy:(1)There was correlation between TCM syndromes and mucosa color.Dark red accounted for the most in large intestine damp-heat syndrome(85.37%),dark purple accounted for the most in excessive heat toxin syndrome(58.33%),light red accounted for the most in spleen deficiency and dampness syndrome(78.57%),cold-heat complex syndrome(45.45%)and liver depression and spleen deficiency syndrome(77.78%).Light white/red white accounted for the most in spleen and kidney Yang deficiency syndrome(57.14%).Light white/red white and dark purple accounted for the most in Yin blood deficiency syndrome(both were 50.00%).(2)There was significant correlation between TCM syndromes and mucosa damage under enteroscope.Congestion,edema,with rough mucosa or blurred vascular texture accounted for the most in large intestine damp-heat syndrome(51.22%),cold-heat complex syndrome(72.73%),liver depression and spleen deficiency syndrome(77.78%)and spleen and kidney Yang deficiency syndrome(62.86%).Ulcer/erosion accounted for the most in excessive heat toxin syndrome(58.33%).Scar/mucosal bridge/pseudopolyp accounted for the most in spleen deficiency and dampness syndrome(54.76%).Congestion,edema,with rough mucosa or blurred vascular texture and ulcer/erosion accounted for the most in Yin blood deficiency syndrome(both were 50.00%).(3)There was significant correlation between TCM syndromes and lesion surface.Yellow/filthy moss accounted for the most in large intestine damp-heat syndrome and excessive heat toxin syndrome(75.00%).White moss accounted for the most in spleen deficiency and dampness syndrome(73.81%)and liver depression and spleen deficiency syndrome(53.33%).No surface attachment accounted for the most in cold-heat complex syndrome(63.64%)and spleen and kidney Yang deficiency syndrome(48.57%).White moss and yellow/filthy moss accounted for the most in Yin blood deficiency syndrome(both were 50.00%).(4)There was significant correlation between TCM syndromes and bleeding condition.Bleeding after contact accounted for the most in large intestine damp-heat syndrome(53.66%).Spontaneous hemorrhage accounted for the most in excessive heat toxin syndrome(50.00%).No bleeding after contact accounted for the most in spleen deficiency and dampness syndrome(92.86%),cold-heat complex syndrome(81.82%),liver depression and spleen deficiency syndrome(91.11%)and spleen and kidney Yang deficiency syndrome(82.86%).No bleeding after contact and Spontaneous hemorrhage accounted for the most in Yin blood deficiency syndrome(both were 50.00%).(5)There was significant correlation between TCM syndromes and mucosa of terminal ileum under enteroscope.Smooth mucosa accounted for the most in large intestine damp-heat syndrome(85.37%),excessive heat toxin syndrome(66.67%),spleen deficiency and dampness syndrome(97.62%),cold-heat complex syndrome(90.91%),liver depression and spleen deficiency syndrome(91.11%)and spleen and kidney Yang deficiency syndrome(94.29%).Smooth mucosa and roughness/edema/congestion with scattered lymphoid follicular hyperplasia accounted for the most in Yin blood deficiency syndrome(50.00%).(6)There was significant correlation between TCM syndromes and range of lesion.E2(left colon)accounted for the most in large intestine damp-heat syndrome(46.34%),cold-heat complex syndrome(63.64%)and liver depression and spleen deficiency syndrome(51.11%).E3(total colon)accounted for the most in excessive heat toxin syndrome(100.00%),spleen deficiency and dampness syndrome(47.62%),spleen and kidney Yang deficiency syndrome(51.43%)and Yin blood deficiency syndrome(100.00%).Conclusion: There was correlation between TCM syndromes and performance under enteroscopy of AUC patients.The performance under enteroscopy can provide clinical basis for TCM syndrome differentiation and promote objectification of TCM syndrome differentiation.