| Objective: To explore the distribution and correlation of TCM constitution and colonoscopy in UC patients,and to provide clinical basis for the prevention and treatment of UC by combining syndrome differentiation,disease differentiation and body differentiation.Methods: For UC patients who meet the inclusion criteria,a special resident physician is responsible for collecting the patient ’s general information and colonoscopy results,and guiding the patient to fill out the TCM constitution determination form to determine the constitution.The collected clinical data were analyzed by statistical software to study the distribution and correlation of TCM constitution and colonoscopy in UC patients.Results: 1.General data analysis(1)A total of 192 UC patients were included in this study,including 106 males and 86 females,with a male to female ratio of 1.23 : 1;the average age of women was 43.56 years old,and the average age of men was 46.51 years old.There was no significant correlation between gender and age(P>0.05).(2)The course of disease was 1～5 years(36.98%),followed by > 10 years(27.08%),6～10 years(25.52%),< 1 year(10.42%).(3)According to the Montreal classification criteria,E3(48.00%)was the most common type in the active range of lesions,followed by E2(38.86%)and E1(13.14%).(4)According to the modified Truelove-Witts disease severity classification standard,severe patients(57.14%)were the most,followed by mild(21.72%)and moderate(21.14%).(5)There was a significant correlation between the course of active disease and the range of lesions(P<0.01).The patients with the course of disease less than 1 year were mainly E3 type(52.63%),followed by E1 type(31.58%)and E2 type(15.79%),The lesion range of patients with a course of 1～5 years and > 10 years was mainly E3 type(41.27%,55.32%),followed by E2 type(36.51%,42.55%),E1(22.22%,2.13%);patients with a course of6～10 years were mainly E3(47.83%)and E2(47.83%),followed by E1(4.34%).(6)There was a significant correlation between the range of active lesions and the severity of the disease(P<0.01).The patients with type E1 were mainly mild(82.60%),followed by moderate(8.70%)and severe(8.70%).Patients with E2 and E3 were mainly severe(51.47% and 75.00%,respectively),followed by moderate(35.29% and 13.10%,respectively)and mild(13.24% and11.90%,respectively).(7)There was no significant correlation between the course of disease and the severity of the disease(P>0.05).2.TCM constitution distribution and its correlation with general data(1)The most common TCM constitution of UC patients was yang deficiency(37.50%),followed by gentleness(19.79%),damp-heat(12.50%),qi deficiency(8.33%),blood stasis(6.77%),phlegm-dampness(5.73%),yin deficiency(5.21%)and qi stagnation(4.17%).(2)There was a correlation between TCM constitution and gender(P< 0.05).Yang deficiency,qi deficiency,phlegm dampness,damp heat and blood stasis are mainly male,yin deficiency,qi stagnation and peace are mainly female.(3)There was a significant correlation between TCM constitution and eating habits(P<0.01).Gentleness,qi deficiency,yang deficiency and blood stasis are more common in non-diet preference,yin deficiency is more common in preference to pickled products,phlegm dampness is more common in preference to sweet food,damp heat is more common in preference to spicy food,and qi stagnation is more common in preference to sour food.(4)There was no significant correlation between TCM constitution and age(P>0.05).(5)There was no significant correlation between TCM constitution and course of disease(P>0.05).3.Colonoscopy image distribution(1)The most common color of mucosa was light red(51.04%),followed by deep red(33.85%),light white / red and white(11.98%),purple and dark(3.13%).(2)The mucosal damage was mainly edema and erosion,which could be accompanied by rough particles / clubbing hyperplasia(57.29%),followed by large area ulcer(27.08%),scar / mucosal bridge / pseudopolyps(15.63%).(3)The most common surface of the lesion was no attachment(45.31%),followed by yellow / dirty moss(33.86%),and white moss(20.83%).(4)Bleeding after contact without bleeding(54.68%)was the most common,followed by bleeding after contact(40.63%),spontaneous bleeding(4.69%)was the least.(5)The smooth mucosa(82.81%)was the most common in the terminal ileum,followed by rough mucosa / edema / congestion(14.06%),mucosal erosion / ulcer formation(3.13%).(6)The most common form of intestinal cavity was that the colonic pouch became shallow and the fold shape was blurred(58.85%),followed by the normal shape of colonic pouch and fold(34.38%).The shape of colonic pouch and fold disappeared completely,and the intestinal cavity was narrow and stiff(6.77%).4.Correlation between TCM constitution and enteroscopy(1)There was a significant correlation between TCM constitution and mucosal color(P<0.01).Gentleness,qi deficiency,yang deficiency and blood stasis are more common in light red,yin deficiency and phlegm dampness are more common in light red and dark red,damp heat is more common in dark red,qi stagnation is more common in light white / red and white and light red.(2)There was a correlation between TCM constitution and mucosal damage(P<0.05).The gentleness,qi deficiency,yang deficiency,yin deficiency,phlegm-dampness and qi stagnation constitutions are mainly edema and erosion.The damp-heat and blood stasis constitutions are mainly large area ulcers.(3)There was no significant correlation between TCM constitution and lesion surface attachment(P>0.05).(4)There was a significant correlation between TCM constitution and bleeding(P<0.01).No bleeding after contact is more common in gentleness,yang deficiency,yin deficiency,phlegm dampness and qi stagnation.Bleeding after contact is more common in qi deficiency,damp heat and blood stasis.(5)There was no significant correlation between TCM constitution and terminal ileum mucosa(P>0.05).(6)There was a significant correlation between TCM constitution and intestinal cavity morphology under colonoscopy(P<0.01).Gentleness is more common in the normal form of colonic pouch and folds.Qi deficiency,Yang deficiency,Yin deficiency,phlegm dampness,damp heat,blood stasis and qi stagnation are more common in the shallow colonic pouch and blurred folds.Conclusion: UC patients have more biased constitution.There is a significant correlation between TCM constitution and colonoscopy.Clinically,syndrome differentiation,disease differentiation and body differentiation can be combined to prevent and treat this disease. |
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