Clinical Observation Of Shengchainingxin Decoction In Treating Ventricular Premature Beat Of Coronary Heart Disease With Heart-Yang Deficiency Combined With Qi Stagnation And Blood Stasis

Objective: Through the clinical observation of Shengchainingxin Decoction treating ventricular premature beats of coronary heart disease with heart-yang deficiency and stagnation of qi and blood syndrome,the mechanism of action and clinical significance were discussed.Methods: In this study,64 patients with ventricular premature beat of coronary heart disease with heart-yang deficiency and stagnation of qi and blood syndrome were randomly divided into the experimental group and the control group with 32 cases each.The control group was treated with conventional western medicine,and the experimental group was treated with Shengchainingxin Decoction on the basis of the control group.The treatment course was 4 weeks.By observing the changes of syndrome score,frequency of premature ventricular beats,proportion of total heart beats,HRV,routine ECG and blood lipid before and after treatment in the two groups,clinical efficacy was evaluated and the safety was evaluated.Results: 1.After treatment,syndrome scores in 2 groups were markedlydecreased(P < 0.01),the total effective rate of syndrome in experimental group was 84.38%,and that in control group was 62.5%,which was significantly higher in experimental group(P < 0.01).Comparison of efficacy of single symptom,the efficacy of experimental group was better than control group on chest swelling and tightness,fatigue,sigh,pale or purple in complexion(P < 0.05).The improvement of the fear of cold limbs cold was significantly better than the control group(P < 0.01).The improvement of the symptoms of palpitation,chest pain,shortness of breath and spontaneous sweating was slightly better than the control group,but there was no significant difference(P > 0.05).It showed that in improving the efficacy of TCM syndrome the experimental group was significantly better.2.In terms of the holter electrocardiogram,the number of Holter ventricular premature beats and the proportion of premature beats to the total number of beats were significantly decreased in both groups after treatment(P < 0.01).The total effective rate of the experimental group and the control group were 87.5% and 65.63%,respectively,and the efficacy of the experimental group was better(P < 0.05).These results illustrated Shengchainingxin Decoction was more effective.After treatment,the Lown grading of the two groups was significantly decreased,and the effective rates of the experimental group and the control group were 87.50% and 71.88%,respectively.The addition of Shengchainingxin Decoction group was more dominant.HRV was significantly increased in both groups(P < 0.01),and SDNN and RMSSD were significantly lowered in Shengchainingxin Decoction group compared with other groups(P < 0.05),indicating that Shengchainingxin Decoction was more beneficial to reduce the risk of malignant cardiovascular events and improve the prognosis of patients.3.In terms of ECG efficacy,the total effective rate of the experimental group and the control group after treatment was 65.63% and 56.25%,and there was no significant difference between the two groups(P > 0.05),showing that the two groups could improve the ECG performance,but there was little difference.4.In terms of blood lipid,all indexes of blood lipid in experimental group were significantly improved after treatment(P < 0.01).In the control group,TG and HDL-C had no significant changes compared with before treatment(P > 0.05).It showed that Shengchainingxin Decoction had a better effect on blood lipid.5.There were no significant abnormalities in safety indexes before and after treatment in 2 groups(P > 0.05),no obvious adverse reactions and adverse events.Conclusions: Shengchainingxin Decoction can higher avail the clinical symptoms of patients and the quality of life of patients,reduce the frequency and proportion of premature ventricular beats,reduce the Lown grade,improve the autonomic nervous function and regulate the blood lipid level,improve the prognosis.Shengchainingxin Decoction is effective,safe and suitable for clinical promotion in treating ventricular premature beat of coronary heart disease with heart-yang deficiency and Qi stagnation and blood stasis.