Correlation Between Aortic Pulse Pressure Index And Coronary Artery Lesions In Patients With Premature Coronary Artery Disease And Its Risk Factors

Objective:1.To explore the relationship between aortal pulse pressure index(PPI)and coronary artery lesions in patients with premature coronary artery disease.2.Compared with patients without coronary artery disease,the aortal PPI level and risk factors of patients with premature coronary artery disease were discussed.Methods:1.A retrospective successive collection of 170 patients(men<55 years old,women<65years old)who had not previously undergone coronary intervention or coronary bypass grafting were included in a retrospective and continuous process,and aortic blood pressure was collected and recorded,PPI were calculated and grouped,and Gensini scores were calculated according to coronary angiography results to explore the relationship between aortic PPI and coronary artery lesions in patients with premature coronary artery disease.2.A retrospective and continuous inclusion of 664 patients(men<55 years and women<65years)who completed coronary angiography were enrolled in two groups: premature coronary artery disease and non-coronary heart disease group.General information,blood test data and coronary angiography data of the two groups were collected to explore the risk factors for premature coronary artery disease.Results:1.The level of aortic PPI is positively correlated with the degree of coronary stenosis in patients with premature coronary artery disease(r=0.328,P<0.001);2.The level of aortic PPI is positively correlated with the extent of coronary artery disease in patients with premature coronary heart disease(r=0.271,P<0.001);3.The proportion of patients with premature coronary artery disease in the aortic PPI≥0.51 group was higher than that in the PPI≤ 0.40 group and the PPI 0.41-0.50 group;4.Proportion of men in the premature coronary artery disease group,BMI,smoking ratio,hypertension,diabetes mellitus,systolic aortic blood pressure,aortic pulse pressure and aortic PPI≥0.51 were higher than those in the non-coronary heart disease group(P<0.05),and the proportion of aortic PPI≤0.40 in the premature coronary artery disease group is smaller than the non-coronary group(P<0.05);5.Patients with premature coronary artery disease had higher levels of blood glucose,triglycerides,creatinine,uric acid,monocytes,lymphocytes,NT-pro BNP,leukocytes,and neutrophils than non-coronary heart disease patients(P<0.05),while non-coronary heart disease patients had higher levels of high-density lipoprotein cholesterol(P<0.001);6.Multivariate regression analysis showed that smoking,aortic pulse pressure,NT-pro BNP and aortic PPI≥0.51 is a risk factor for premature coronary artery disease(P<0.05);7.Proportion of diabetes history in the group with multiple lesions of premature coronary artery disease,blood glucose,triglycerides,NT-pro BNP and aortic PPI were higher than those in the single lesion group(P<0.05);8.Multivariate regression analysis showed that aortic PPI level was an independent risk factor for multivessel disease in premature coronary artery disease(P=0.012).Conclusions:1.The aortic PPI of patients with premature coronary artery disease was positively correlated with the degree of coronary lesions,and the proportion of three coronary lesions in patients with PPI≥0.51 was higher than that in other groups,which was of guiding significance for the assessment of the severity of coronary lesions;2.Smoking history,aortic pulse pressure difference,aortic PPI(≥0.51),and NT-pro BNP were independent risk factors for premature coronary artery disease,and aortic PPI was the most significant independent risk factor for premature coronary artery disease;3.The level of aortic PPI was positively correlated with the number of coronary artery lesions in patients with premature coronary artery disease,and the increase of aortic PPI would lead to an increased risk of multi-vessel disease in patients with premature coronary artery disease,suggesting that aortic PPI was an independent risk factor for multi-vessel lesions.