| Objective:Visuospatial,one of the most commonly affected cognitive domains after stroke,affects the recovery of motor function and basic self-care ability of stroke patients.Mental rotation is an important criterion for measuring visuospatial cognition.As the related behavioral responses and electrophysiological characteristics of patients with post-stroke cognitive impairment(PSCI)are still unclear,our study here combined cognitive function assessment scale,mental rotation task,resting-state EEG,and eventrelated potentials,in order to explore the visuospatial function of patients with PSCI from the perspective of behavior and electrophysiology.Methods:12 patients with PSCI and 11 patients without cognitive impairment after stroke(post-stroke non-cognitive impairment,PSNCI)were enrolled.Patients were secondly grouped into visuospatial dysfunction group(VSD)and nonvisuospatial dysfunction group(NVSD)according to clock drawing test,with 10 VSD and 13 NVSD patients respectively.After the clinical cognitive assessment scales were assessed,resting EEG of the patients was recorded,with the mental rotation task simultaneously carried out.The patients were asked to judge whether the hand picture rotated at 0°,60°,120°,180°,240° and 300°was the left hand or the right hand.The accuracy,reaction time and EEG data of the subjects were collected during the experiment.The power of delta wave,theta wave,alpha wave and beta wave in resting state and P300 components reflecting the cognitive stage of mental rotation were measured.The differences of behavioral data and EEG components between groups were compared,and the characteristics of visual spatial impairment in patients with cognitive impairment after stroke were analyzed.Results:①Cognitive scales:statistical differences were found in scores of MoCA,revised Hopkins vocabulary learning test and the Rey-Osterreith complex figure test between PSCI group and PSNCI group(P<0.05).Statistical differences were found in Boston naming test,clock drawing test and Rey-Osterreith complex figure copying test between VSD group and NVSD group(P<0.05).②Behavioral data:the accuracy rate of PSCI group was lower than that of PSNCI group showing a significant"angle effect".There was no statistical difference in the reaction time between the two groups(P>0.05).Scores of Rey-Osterreith complex figure copying test were positively correlated with the accuracy rate of the rotation task(P<0.05),and negatively correlated with the reaction time(P<0.05).③The delta power of PSCI group in frontal area and parieto-occipital area was higher than that of PSNCI group(P<0.05).The resting state EEG showed that the alpha power in the parietal lobe in VSD group was higher than that in NVSD group(P<0.05),and the delta and theta power in VSD group in the frontal and parieto-occipital regions were higher than those in NVSD group(P<0.05).④Results of ERP showed that the P300 amplitudes of NVSD group with angles 0°,60°,and 300° were higher than those with angles 120°,180°,and 240°(P<0.05).When stimulating pictures were of left hand,the amplitude of P300 with angles 120°,180°,and 240° was lower than that of right hand(P<0.05).Conclusions:①Performance of the mental rotation task in patients who were affected in visuospatial and memorial domains was worse(accuracy decreased).②The accuracy rate of all stroke patients showed an "angle effect".The closer the hand rotation angle was to 180°,the lower the accuracy rate were.③Resting-state EEG suggested that VSD patients possibly had lower demand for visuospatial representation.④The stage of visual encoding in the mental rotation task was roughly the same for overall stroke patients,but VSD patients were not sensitive to spatial angles.⑤ReyOsterreith complex figure copying test scores were helpful for detecting visuospatial dysfunction after stroke. |
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