Objective:Probe into prescriptions in Treatise on Febrile Diseases applicable to edemas as well as into Dialectical Therapy Rules on edemas quoted by Treatise on Febrile Diseases,in order to provide ideas and methods for clinical diagnosis and therapies as well as theoretical foundations for clinical medications.Methods:With philology study methods and time sequence,sources and courses of edemas are sorted out;causes,pathogenesis,symptoms and physical signs of edemas are summarized and concluded into swelling,fullness,coughing,panting,sweating sickness,thirst;weak breath,diarrhea,difficult urination,vomiturition,heavy pain,sunken and tight pulse,etc.Etiology and pathogenesis of edemas are recognized as body resistance weakened while pathogenic factors prevailing and Qi dysfunction.Edemas are mostly caused by cold-evil and circulation disorder of Qi and blood.Therefore,edemas are recognized more systemically and more comprehensively from multiple angles.Prescriptions applicable to edemas are picked out from Treatise on Febrile Diseases by causes,pathogenesis,symptoms and physical signs of edemas and are added to different parts of The Six Channels.Then statistical approaches are adopted to study dialectical therapy rules on edemas quoted by Treatise on Febrile Diseases.Firstly,enter the selected 32 prescriptions and medicines applicable to edemas into Excel 2019 table;Then,with SPSS Statistics 21.0 and SPSS Modeler 18.0 software,respectively perform frequency statistics,clustering analysis and association rules analysis to medication frequencies,medicine channel tropisms and high frequency medicines.Results:among 32 prescriptions applicable to edemas,50 medicines are nonrepeating.Via filtration,those medicines whose medication frequency≥3 are defined as high frequency medicines.These medicines total 17,among which bitterness,sweetness,hotness,coldness,warmness cover the most proportion in properties and flavors,mainly act through channels of lung,stomach,spleen,kidney and heart.According to nature flavors and channel tropisms of different medicines,they cover a variety of proportions in the sex parts of Treatise on Febrile Diseases.For example,most medicines warm in nature are present in the part of "Taiyin diseases",while most medicines cold in nature are present in in the part of Shaoyang;most medicines sweet in flavor are present in the parts of "Taiyin diseases"and Shaoyin diseases",while most medicines bitter in flavor are present in the part of "Shaoyang diseases";most medicines acting through lung channels are present in the part of "Taiyang disease",while most medicines acting through spleen channel are present in the part of "Taiyin disease".According to sorting techniques of Science of Chinese Traditional Medicine,among 50 medicines,those who function to tonify deficiency,those who function to prevent phlegm from forming and stop coughing,those who function to relieve exterior syndrome,and those who function to clear damp and promote diuresis cover relatively higher proportions.Moreover,medicines of different groups respectively accounts for different proportions of each part of Six Channels;in the parts of"Taiyin diseases" and "Shaoyin diseases",the medicines who function to tonify deficiency are present with higher frequency;while in Taiyang diseases,the medicines who function to tonify deficiency are present with higher frequency.According to clustering analysis conclusions,these 17 high frequency medicines are divided into 4 groups,including "supplement Qi to warm yang" group,"combination of supplementing and dispersing"group,"tonifying Qi and dispelling cold" and "heat-clearing and dampdrying" group as well as "benefiting Qi for activating blood circulation"and "sweating and hydragogue" group.Inner-group or inter-group medicines are compatible to each other,functioning to regulate Qi and disperse fluid.By analysis,these high-frequency medicine pairs performed in accordance with association rules include the cassia twig-liquorice,fresh ginger-Chinese date,ginseng-pinellia ternata-Chinese date,rhizoma zingiberis-pinellia-scutellaria baicalensis and bighead atractylodes rhizome-radix paeoniae alba-monkshood,etc.Especially,cassia twigliquorice pair widely exists in all parts of Treatise on Febrile Diseases.Conclusion:The main causes of edemas are concluded as "body resistance weakened while pathogenic factors prevailing" and Qi dysfuntion.The Qi dysfuntion resulted from Qi disorder are concluded as the direct cause of water-humor distribution barriers’ arise.In treating edemas with Treatise on Febrile Diseases,attentions are paid to "deficiency in origin";therefore,medicines that support healthy energy can be found in all parts of Treatise on Febrile Diseases,centering on restoring internal deficiencies and dispelling internal cold.In the case of weak vital energy with strong resistance to medication,the principle of "stopgap measures be taken in the case of emergencies" should be followed,in order to preceding relieving sufferers from pains to treating them with medical measures.In treating Taiyang edemas,such therapeutic measures as"relieving exterior syndrome by diaphoresis","resolving sputum and relieving asthma","warming Yang and transforming Qi",as well as"purgating excessive fluid" should be taken;in treating Yangming edemas,such therapeutic measures as "warming the stomach and dispersing the fluid"and "harmonizing the stomach and calm the adverse-rising energy" as well as "both supplementing and dispersing measures" should be taken;in treating Shaoyang edemas,such therapeutic measures as "revolving the cardinals,combing frigotherapy and pyretotherapy" should be taken;in treating Taiyin edemas,such therapeutic measures as "warming middle-jiao and tonifying deficiency" should be taken;in treating Shaoyin edemas,such therapeutic measures as "warming the yang and promoting diuresis"as well as "clearing damp and promoting diuresis" should be taken. |