Changes Of Choroidal And Retinal Nerve Fiber Layer Thickness And Their Correlation Factors In Young Adults With Myopia

Purposes:We aimed to analyze the characteristics of the choroidal thickness(ChT)and peripapillary retinal nerve fiber layer(RNFL)thickness,and their correlation with axial length and the position of retinal blood vessels in young myopic adults.Methods:This study was a cross-sectional study.A total of 224 eye samples from 135 participants who were treated in the ophthalmology department of Shandong Provincial Hospital Hospital from April 2022 to June 2022 were randomly collected.Based on axial length(AL),patients were divided into the emmetropia group,mild-myopia group,moderate-myopia group,and highmyopia group.Each participant underwent basic ocular examinations.SS-OCTA was used to measure the choroidal thickness,optic disc-related anatomical parameters,peripapillary retinal nerve fiber layer thickness and RPC VD,The Image J system were used to measure the peripapillary retinal artery angle.SPSS 25.0 statistical software was used for data analysis.Results:The choroidal thickness in the posterior pole was thinner as myopia worsened(P<0.05).The regional distribution of choroidal at the posterior pole of the four groups were different.In the macular region,the choroid in the emmetropia group,mild-myopia group,and highmyopia group were thickest in the temporal sector and thinnest in the nasal sector;The choroid in the moderate-myopia group was thickest in the superior sector and thinnest in the nasal sector.In the optic disk region,the choroid in each group were thickest in the superior sector and thinnest in the inferior sector.Center fovea,and the macular-papillary region showed the most significant decrease in choroidal thickness in high myopes compared to emmetropia group.AL was negatively correlated with the choroidal thickness in both the macular and optic disc areas(all P<0.05).The average RNFL thickness was significantly different among four groups(P<0.05).RNFL thickness of the four groups was statistically significant only in the SN,NU,NL,IN,IT,TL quadrants(all P<0.05),RNFL thickness in the residual quadrant showed no significant difference between groups(all P>0.05).The RNFL thickness of the ST,SN,NU,NL,IN,IT quadrant were negatively correlated with AL(all P<0.05),and only the RNFL thickness in the TL quadrant was positively correlated with AL(P=0.015).There was no correlation between RNFL thickness and AL in the TU quadrant(P>0.05).The RNFL thickness and RPC VD showed a significant positive correlation in each group(all P<0.001).The disc area and rim area were significantly different among four groups(all P<0.05).AL was negatively correlated with the disc area,rim area and angle a(all P<0.05).The RNFL thickness of the SN,NU,IN quadrant were positively correlated with angle a(all P<0.05),and only the RNFL thickness in the TL quadrant was negatively correlated with angle a(P=0.015).There was no correlation between RNFL thickness and angle a in the residual quadrants(all P>0.05).The choroidal thickness in the macular region was positively correlated with angle α(P<0.05),and only the choroidal thickness in the temporal sector was positively correlated with angle α(P=0.016).Conclusion:The angle α,disc area,and rim area were closely related to AL among the optic discrelated anatomical parameters.With the decrease of angle a and the elongation of AL,the choroidal thickness in the posterior pole was thinner.The peripapillary RNFL thickness was thinner in the nasal quadrant of the optic disc with the decrease of angle a and the elongation of AL.The peripapillary RNFL thickness was thicker in the temporal quadrant of the optic disc with the decrease of angle α and the elongation of AL.And the peripapillary RNFL thickness was correlated with RPC VD1.Choroidal in the posterior pole and peripapillary RNFL thinning might be uneven during the development of myopia.2.With the elongation of AL,the choroidal thickness in the posterior pole and the peripapillary RNFL thickness in the nasal quadrant of the optic disc was thinner,the peripapillary RNFL thickness in the temporal quadrant of the optic disc was thicker.3.The peripapillary retinal artery angle was related with choroidal and peripapillary RNFL thickness.