The Effect Of Nutritional Intervention On Metabolism And Intestinal Flora In Overweight And Obese Patients With Polycystic Ovary Syndrome

BackgroundPolycystic ovary syndrome(PCOS)was a common endocrine and metabolic disease in reproductive women,which was associated with visceral obesity,obesity,insulin resistance,dyslipidemia,nonalcoholic fatty liver(NAFLD),and cardiovascular disease.Previous studies had shown that the gut microbiota of PCOS patients had significant differences from those of healthy individuals,which may play an important role in the pathogenesis of PCOS.Lifestyle intervention,such as nutritional intervention,could improve the metabolic profiles and PCOSlike phenotypes of PCOS patients.Meanwhile,nutritional intervention could rapidly alter and reshape the distribution of gut microbiota in individuals.Therefore,we sought to investigate the differences in gut microbiota in overweight and obese PCOS patients with or without nutritional intervention.MethodsThirty-six overweight and obese PCOS patients were finally enrolled in the study.18 individuals who refused nutritional intervention(RNI)were collected as the RNI group.18 individuals who received the nutritional intervention were collected as the pre-NI group before the nutritional intervention.And they were also collected as the NI group after the nutritional intervention for 4-12 weeks.Changes in body mass index(BMI),fasting blood glucose(FBG),total cholesterol(T G),triglycerides(TC),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(APO A1),apolipoprotein B(APO B),and the relative abundance of gut microbiota and genes were evaluated.ResultsComparing to the pre-NI group,patients in the NI group showed significant decreases in BMI,FBG,TC,TG,APO A1,and APO B after the nutritional intervention for 4-12 weeks.Comparing to the RNI group,patients in the NI group also showed significant decreases in TC,TG,APO A1,and APO B.Meanwhile,the differences in the phylum Firmicutes,Bacteroidetes,and the species Eubacterium rectale,Flavonifractor plautii,and Bacteroides vulgatus between the NI and the RNI groups were observed.ConclusionSignificant differences in metabolic profiles were observed between the NI group and RNI group.At the same time,significant differences in gut microbiota were also observed between the two groups,which may be potentially linked to the improved inflammatory state and PCOSlike phenotypes of overweight and obese PCOS individuals.